Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C27H35N5O2.ClH |
| Molecular Weight | 498.06 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC1(C)CCC(=CC1)C2=NC(=CC=C2NC(=O)C3=NC=C(N3)C#N)C4CC(C)(C)OC(C)(C)C4
InChI
InChIKey=GDFIUUZLRLJTSJ-UHFFFAOYSA-N
InChI=1S/C27H35N5O2.ClH/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)34-27(5,6)14-18;/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33);1H
| Molecular Formula | C27H35N5O2 |
| Molecular Weight | 461.5991 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
278 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
150 mg single, oral dose: 150 mg route of administration: Oral experiment type: SINGLE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
552 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
358 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
600 mg single, oral dose: 600 mg route of administration: Oral experiment type: SINGLE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
313 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
150 mg 2 times / day multiple, oral dose: 150 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
598 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
300 mg 1 times / day steady-state, oral dose: 300 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
1157 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
450 mg 1 times / day steady-state, oral dose: 450 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
843 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
600 mg 1 times / day steady-state, oral dose: 600 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
483 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
150 mg 2 times / day steady-state, oral dose: 150 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
1931 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
150 mg single, oral dose: 150 mg route of administration: Oral experiment type: SINGLE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
3935 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
2657 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
600 mg single, oral dose: 600 mg route of administration: Oral experiment type: SINGLE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
7588 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
300 mg 1 times / day steady-state, oral dose: 300 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
12804 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
450 mg 1 times / day steady-state, oral dose: 450 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
6961 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
600 mg 1 times / day steady-state, oral dose: 600 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
7471 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
150 mg 2 times / day steady-state, oral dose: 150 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
6.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25628399/ |
600 mg 1 times / day steady-state, oral dose: 600 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
140 h |
150 mg 2 times / day multiple, oral dose: 150 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
Funbound
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
1% |
150 mg 2 times / day multiple, oral dose: 150 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
EDICOTINIB plasma | Homo sapiens population: UNHEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 03:58:23 GMT 2025
by
admin
on
Wed Apr 02 03:58:23 GMT 2025
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| Record UNII |
VV40HB3E58
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| Record Status |
Validated (UNII)
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| Record Version |
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-
Download
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Official Name | English | ||
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Preferred Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
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1559069-92-9
Created by
admin on Wed Apr 02 03:58:23 GMT 2025 , Edited by admin on Wed Apr 02 03:58:23 GMT 2025
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1142364-35-9
Created by
admin on Wed Apr 02 03:58:23 GMT 2025 , Edited by admin on Wed Apr 02 03:58:23 GMT 2025
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NON-SPECIFIC STOICHIOMETRY | |||
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VV40HB3E58
Created by
admin on Wed Apr 02 03:58:23 GMT 2025 , Edited by admin on Wed Apr 02 03:58:23 GMT 2025
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25230467
Created by
admin on Wed Apr 02 03:58:23 GMT 2025 , Edited by admin on Wed Apr 02 03:58:23 GMT 2025
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FG-95
Created by
admin on Wed Apr 02 03:58:23 GMT 2025 , Edited by admin on Wed Apr 02 03:58:23 GMT 2025
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300000011156
Created by
admin on Wed Apr 02 03:58:23 GMT 2025 , Edited by admin on Wed Apr 02 03:58:23 GMT 2025
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C169927
Created by
admin on Wed Apr 02 03:58:23 GMT 2025 , Edited by admin on Wed Apr 02 03:58:23 GMT 2025
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PRIMARY |
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