THYROID HORMONE RECEPTOR ALPHA

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 16:49:28 GMT 2025` Edited by `admin` on `Tue Apr 01 16:49:28 GMT 2025`
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	X1D4Q9O3NS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THYROID HORMONE RECEPTOR ALPHA

Common Name

English

C-ERBA-ALPHA

Preferred Name

English

THRA1

Common Name

English

THRA2

Common Name

English

NUCLEAR RECEPTOR SUBFAMILY 1 GROUP A MEMBER 1

Common Name

English

ERBA1

Common Name

English

V-ERBA-RELATED PROTEIN 7

Common Name

English

EAR7

Common Name

English

NR1A1

Common Name

English

Code System Code Type Description

FDA UNII

X1D4Q9O3NS

Created by admin on Tue Apr 01 16:49:28 GMT 2025 , Edited by admin on Tue Apr 01 16:49:28 GMT 2025

PRIMARY

UNIPROT

P10827

Created by admin on Tue Apr 01 16:49:28 GMT 2025 , Edited by admin on Tue Apr 01 16:49:28 GMT 2025

PRIMARY

Linkage Type	Residue Index
ZINC FINGER	1_53	1_73
ZINC FINGER	1_91	1_115

Related Record Type Details


					9YY9X4HSE2

3,5-DIMETHYL-3'-ISOPROPYL-L-THYRONINE

MIMETIC->TARGET


					RE0V0T1ES0

Resmetirom

PARTIAL AGONIST->TARGET

Comments:

Emax=48.6% efficacy for resmetirom relative to T3,

Qualification:

EC50

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL