SOLUTE CARRIER FAMILY 12 MEMBER 3

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 20:58:21 GMT 2025` Edited by `admin` on `Tue Apr 01 20:58:21 GMT 2025`
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	X8CS9QK0G8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NA-CL COTRANSPORTER

Preferred Name

English

SOLUTE CARRIER FAMILY 12 MEMBER 3

Common Name

English

THIAZIDE-SENSITIVE SODIUM-CHLORIDE COTRANSPORTER

Common Name

English

SLC12A3

Common Name

English

Sodium-chloride symporter

Common Name

English

NCC (PROTEIN)

Common Name

English

NA-CL SYMPORTER

Common Name

English

TSC (PROTEIN)

Common Name

English

Code System Code Type Description

FDA UNII

X8CS9QK0G8

Created by admin on Tue Apr 01 20:58:21 GMT 2025 , Edited by admin on Tue Apr 01 20:58:21 GMT 2025

PRIMARY

UNIPROT

P55017

Created by admin on Tue Apr 01 20:58:21 GMT 2025 , Edited by admin on Tue Apr 01 20:58:21 GMT 2025

PRIMARY

WIKIPEDIA

Sodium-chloride symporter

Created by admin on Tue Apr 01 20:58:21 GMT 2025 , Edited by admin on Tue Apr 01 20:58:21 GMT 2025

PRIMARY

Glycosylation Link Type	Site
N	1_406
N	1_426

Related Record Type Details


					0J48LPH2TH

HYDROCHLOROTHIAZIDE

INHIBITOR -> TARGET

Amount:


					5Q52X6ICJI

BENDROFLUMETHIAZIDE

INHIBITOR -> TARGET

Amount:


					36780APV5N

POLYTHIAZIDE

INHIBITOR -> TARGET

Amount:


					1TD8J48L61

BENZTHIAZIDE

INHIBITOR -> TARGET

Amount:


					Q58C92TUN0

TRICHLORMETHIAZIDE

INHIBITOR -> TARGET

Amount:


					F089I0511L

INDAPAMIDE

INHIBITOR -> TARGET

Comments:

indapamide has both diuretic and vasodilator properties. A low urinary excretion and specific accumulation into arterial smooth muscle of this lipophilic molecule may provide a rationale for this dual activity.

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL