EPIDERMAL GROWTH FACTOR RECEPTOR T790M MUTANT

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 19:39:05 GMT 2025` Edited by `admin` on `Tue Apr 01 19:39:05 GMT 2025`
Protein Type	RECEPTOR
Protein Sub Type	GROWTH FACTOR RECEPTOR
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	Z8GA0YQ49Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EGFR T790M

Preferred Name

English

EPIDERMAL GROWTH FACTOR RECEPTOR T790M MUTANT

Common Name

English

T790M

Common Name

English

EGFR T790M MUTATION

Common Name

English

THR790MET

Common Name

English

Code System Code Type Description

EC (ENZYME CLASS)

EC 2.7.10.1

Created by admin on Tue Apr 01 19:39:05 GMT 2025 , Edited by admin on Tue Apr 01 19:39:05 GMT 2025

PRIMARY

UNIPROT

P00533

Created by admin on Tue Apr 01 19:39:05 GMT 2025 , Edited by admin on Tue Apr 01 19:39:05 GMT 2025

PRIMARY

FDA UNII

Z8GA0YQ49Y

Created by admin on Tue Apr 01 19:39:05 GMT 2025 , Edited by admin on Tue Apr 01 19:39:05 GMT 2025

PRIMARY

WIKIPEDIA

T790M

Created by admin on Tue Apr 01 19:39:05 GMT 2025 , Edited by admin on Tue Apr 01 19:39:05 GMT 2025

PRIMARY

From	To
1_7	1_34
1_133	1_163
1_166	1_175
1_170	1_183
1_191	1_199
1_195	1_207
1_208	1_216
1_212	1_224
1_227	1_236
1_240	1_267
1_271	1_283
1_287	1_302
1_305	1_309
1_313	1_338
1_446	1_475
1_482	1_491
1_486	1_499
1_502	1_511
1_515	1_531
1_534	1_547
1_538	1_555
1_558	1_567
1_571	1_593
1_596	1_604
1_600	1_612

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_32
N	1_49
N	1_104
N	1_151
N	1_172
N	1_328
N	1_337
N	1_389
N	1_420
N	1_504
N	1_544
N	1_579
N	1_599

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Structural Modifications

Modification Type	Location Site	Residue Modified	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_1175]	ARGININE	TILARGININE	27JT06E6GR
AMINO ACID SUBSTITUTION	[1_974] [1_992] [1_1068] [1_1086] [1_1148] [1_1173]	TYROSINE	TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO ACID SUBSTITUTION	[1_654]	THREONINE	THREONINE PHOSPHATE	3L4WX7B1EI

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)	CHEMICAL