RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 D769H MUTANT

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:53:17 GMT 2025` Edited by `admin` on `Wed Apr 02 13:53:17 GMT 2025`
Protein Type	RECEPTOR
Protein Sub Type	TYROSINE KINASE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	ZY2PMB7WG4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ERBB-2 D769H

Preferred Name

English

RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 D769H MUTANT

Common Name

English

HER2 (D769H)

Common Name

English

HER-2 D769H

Common Name

English

Code System Code Type Description

UNIPROT

P04626

Created by admin on Wed Apr 02 13:53:17 GMT 2025 , Edited by admin on Wed Apr 02 13:53:17 GMT 2025

PRIMARY

FDA UNII

ZY2PMB7WG4

Created by admin on Wed Apr 02 13:53:17 GMT 2025 , Edited by admin on Wed Apr 02 13:53:17 GMT 2025

PRIMARY

From	To
1_4	1_31
1_140	1_170
1_173	1_182
1_177	1_190
1_198	1_205
1_202	1_213
1_214	1_222
1_218	1_230
1_233	1_242
1_246	1_273
1_277	1_289
1_293	1_309
1_312	1_316
1_320	1_345
1_453	1_482
1_489	1_498
1_493	1_506
1_509	1_518
1_522	1_538
1_541	1_554
1_545	1_562
1_565	1_574
1_578	1_601
1_604	1_612
1_608	1_620

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_46
N	1_102
N	1_165
N	1_237
N	1_508
N	1_549
N	1_607

Related Record Type Details


					JJH94R3PWB

NERATINIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					CJN36EQM0H

PYROTINIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					EP2QR4P7ZL

SPH-5030

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_1117] [1_1174] [1_1226]		TYROSINE		TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO ACID SUBSTITUTION	[1_1032] [1_1056] [1_1061] [1_1085] [1_1129]		SERINE		DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL

MOL_WEIGHT	CHEMICAL