HOQUIZIL

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H26N4O5
Molecular Weight	390.4335
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of HOQUIZIL

Structure Search

SMILES

COC1=CC2=NC=NC(N3CCN(CC3)C(=O)OCC(C)(C)O)=C2C=C1OC

InChI

InChIKey=YRTMGQYDLITGNA-UHFFFAOYSA-N

InChI=1S/C19H26N4O5/c1-19(2,25)11-28-18(24)23-7-5-22(6-8-23)17-13-9-15(26-3)16(27-4)10-14(13)20-12-21-17/h9-10,12,25H,5-8,11H2,1-4H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4912116 | https://www.ncbi.nlm.nih.gov/pubmed/6276530

Hoquizil, a phosphodiesterase inhibitor, was used as a bronchodilator agent. Information about the current use of this drug is not available.

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
phosphoric diester hydrolase activity 4 Target ID: GO:0008081 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6276530	Inhibitor 8504

PubMed

PubMed

Title	Date	PubMed
Heterogeneity of biochemical actions among vasodilators.	1982-01	6276530
Quinazolines in man. Metabolism and preliminary evaluation of piquizil and hoquizil, two bronchodilators.	1971	4946165
Hoquizil--a new oral bronchodilator. A double-blind, randomized, coded clinical study using body plethysmography.	1969	4912116

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

Name

Type

Language

1-PIPERAZINECARBOXYLIC ACID, 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-, 2-HYDROXY-2-METHYLPROPYL ESTER

Preferred Name

English

HOQUIZIL

Official Name

English

hoquizil [INN]

Common Name

English

2-HYDROXY-2-METHYLPROPYL 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-1-PIPERAZINECARBOXYLATE

Systematic Name

English

Code System Code Type Description

CAS

21560-59-8

Created by admin on Wed Apr 02 07:35:18 GMT 2025 , Edited by admin on Wed Apr 02 07:35:18 GMT 2025

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EVMPD

SUB08056MIG

Created by admin on Wed Apr 02 07:35:18 GMT 2025 , Edited by admin on Wed Apr 02 07:35:18 GMT 2025

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INN

2634

Created by admin on Wed Apr 02 07:35:18 GMT 2025 , Edited by admin on Wed Apr 02 07:35:18 GMT 2025

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FDA UNII

2MP2H1GQ03

Created by admin on Wed Apr 02 07:35:18 GMT 2025 , Edited by admin on Wed Apr 02 07:35:18 GMT 2025

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EPA CompTox

DTXSID30175896

Created by admin on Wed Apr 02 07:35:18 GMT 2025 , Edited by admin on Wed Apr 02 07:35:18 GMT 2025

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SMS_ID

100000084191

Created by admin on Wed Apr 02 07:35:18 GMT 2025 , Edited by admin on Wed Apr 02 07:35:18 GMT 2025

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NCI_THESAURUS

C166582

Created by admin on Wed Apr 02 07:35:18 GMT 2025 , Edited by admin on Wed Apr 02 07:35:18 GMT 2025

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ChEMBL

CHEMBL2110858

Created by admin on Wed Apr 02 07:35:18 GMT 2025 , Edited by admin on Wed Apr 02 07:35:18 GMT 2025

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PUBCHEM

30690

Created by admin on Wed Apr 02 07:35:18 GMT 2025 , Edited by admin on Wed Apr 02 07:35:18 GMT 2025

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ACTIVE MOIETY


					2MP2H1GQ03

HOQUIZIL

SALT/SOLVATE (PARENT)


					9I598ZX18I

HOQUIZIL HYDROCHLORIDE