BUPROPION

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H18ClNO
Molecular Weight	239.741
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of BUPROPION

Structure Search

SMILES

CC(NC(C)(C)C)C(=O)C1=CC(Cl)=CC=C1

InChI

InChIKey=SNPPWIUOZRMYNY-UHFFFAOYSA-N

InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3

HIDE SMILES / InChI

Molecular Formula	C13H18ClNO
Molecular Weight	239.741
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:50:10 UTC 2023` Edited by `admin` on `Sat Dec 16 16:50:10 UTC 2023`
Record UNII	01ZG3TPX31
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BUPROPION

Official Name

English

NSC-758686

Code

English

BUPROPION [MI]

Common Name

English

BUPROPION SLOW RELEASE

Common Name

English

AMFEBUTAMONE

Common Name

English

1-PROPANONE, 1-(3-CHLOROPHENYL)-2-((1,1-DIMETHYLETHYL)AMINO)-(±)-

Systematic Name

English

Bupropion [WHO-DD]

Common Name

English

bupropion [INN]

Common Name

English

(±)-2-(TERT-BUTYLAMINO)-3'-CHLOROPROPIOPHENONE

Systematic Name

English

BUPROPION COMPONENT OF CONTRAVE

Brand Name

English

BUPROPION [VANDF]

Common Name

English

BUPROPION EXTENDED RELEASE

Common Name

English

BUPROPION [MART.]

Common Name

English

Classification Tree Code System Code

WHO-ATC

N06AX12

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

LIVERTOX

NBK559444

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

NDF-RT

N0000009282

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

NDF-RT

N0000000114

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

WHO-VATC

QN06AX12

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

WHO-ATC

A08AA62

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

NDF-RT

N0000009456

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

NDF-RT

N0000000102

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

NCI_THESAURUS

C265

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

NDF-RT

N0000180855

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

Code System Code Type Description

CHEBI

3219

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

SMS_ID

100000088891

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

INN

3562

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

MERCK INDEX

m2773

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

Merck Index

DRUG BANK

DB01156

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

NCI_THESAURUS

C62012

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

WIKIPEDIA

BUPROPION

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

LACTMED

Bupropion

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

RXCUI

42347

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

RxNorm

EPA CompTox

DTXSID7022706

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

DRUG CENTRAL

435

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

CAS

34841-39-9

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

SUPERSEDED

NSC

758686

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

FDA UNII

01ZG3TPX31

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

DAILYMED

01ZG3TPX31

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

MESH

D016642

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

CAS

34911-55-2

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

ChEMBL

CHEMBL894

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

PUBCHEM

444

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

EVMPD

SUB05413MIG

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

HSDB

6988

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

IUPHAR

7135

Created by admin on Sat Dec 16 16:50:12 UTC 2023 , Edited by admin on Sat Dec 16 16:50:12 UTC 2023

PRIMARY

Related Record Type Details


					8KZL6AO7H4

BUPROPION, (R)-

ENANTIOMER -> RACEMATE


					0UY97CSG1T

CYTOCHROME P450 2B6

METABOLIC ENZYME -> SUBSTRATE


					26NV8NXO4A

BUPROPION MALEATE

SALT/SOLVATE -> PARENT


					01ZG3TPX31

BUPROPION

EXCRETED UNCHANGED

Qualification:

FECAL; URINE

Amount:


					E70G3G5863

BUPROPION HYDROBROMIDE

SALT/SOLVATE -> PARENT


					8E4LAA4357

CYTOCHROME P450 2D6

METABOLIC ENZYME -> INHIBITOR

Comments:

Strong Inhibitors(2) 5-fold increase in AUC or > 80% decrease in CL

Interaction Type:

MAJOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					ZG7E5POY8O

BUPROPION HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					69BL03TL5X

BUPROPION, (S)-

ENANTIOMER -> RACEMATE

Related Record Type Details


					Q47741214K

METABOLITE ACTIVE -> PARENT


					V94F513635

HYDROXYBUPROPION, (±)-

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

PLASMA


					YI65RR2TFJ

ERYTHROHYDROBUPROPION

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

PLASMA


					988C8SFV4F

THREOHYDROBUPROPION

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

PLASMA

Related Record Type Details


					01ZG3TPX31

BUPROPION

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				FASTED STATE ORAL ADMINISTRATION SINGLE DOSE

Tmax	PHARMACOKINETIC				SINGLE DOSE ORAL ADMINISTRATION FED CONDITION