Norfenfluramine

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NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C10H12F3N
Molecular Weight	203.2042
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of Norfenfluramine

Structure Search

SMILES

CC(N)CC1=CC=CC(=C1)C(F)(F)F

InChI

InChIKey=MLBHFBKZUPLWBD-UHFFFAOYSA-N

InChI=1S/C10H12F3N/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13/h2-4,6-7H,5,14H2,1H3

HIDE SMILES / InChI

Molecular Formula	C10H12F3N
Molecular Weight	203.2042
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:53:23 GMT 2025` Edited by `admin` on `Mon Mar 31 22:53:23 GMT 2025`
Record UNII	037A9J3PSW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NSC-43036

Preferred Name

English

Norfenfluramine

Common Name

English

JP-92

Common Name

English

DL-NORFENFLURAMINE

Common Name

English

BENZENEETHANAMINE, .ALPHA.-METHYL-3-(TRIFLUOROMETHYL)-

Systematic Name

English

2-AMINO-1-(3-(TRIFLUOROMETHYL)PHENYL)PROPANE

Systematic Name

English

DESETHYLFENFLURAMINE

Common Name

English

(±)-2-AMINO-1-(3'-TRIFLUOROMETHYLPHENYL)PROPANE

Common Name

English

(±)-NORFENFLURAMINE

Common Name

English

.ALPHA.-METHYL-3-(TRIFLUOROMETHYL)BENZENEETHANAMINE

Systematic Name

English

1-(M-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE

Systematic Name

English

Code System Code Type Description

CAS

1886-26-6

Created by admin on Mon Mar 31 22:53:23 GMT 2025 , Edited by admin on Mon Mar 31 22:53:23 GMT 2025

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NSC

43036

Created by admin on Mon Mar 31 22:53:23 GMT 2025 , Edited by admin on Mon Mar 31 22:53:23 GMT 2025

PRIMARY

EPA CompTox

DTXSID60904717

Created by admin on Mon Mar 31 22:53:23 GMT 2025 , Edited by admin on Mon Mar 31 22:53:23 GMT 2025

PRIMARY

PUBCHEM

15897

Created by admin on Mon Mar 31 22:53:23 GMT 2025 , Edited by admin on Mon Mar 31 22:53:23 GMT 2025

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FDA UNII

037A9J3PSW

Created by admin on Mon Mar 31 22:53:23 GMT 2025 , Edited by admin on Mon Mar 31 22:53:23 GMT 2025

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WIKIPEDIA

Norfenfluramine

Created by admin on Mon Mar 31 22:53:23 GMT 2025 , Edited by admin on Mon Mar 31 22:53:23 GMT 2025

PRIMARY

Related Record Type Details


					ODG984O60W

NORFENFLURAMINE, (R)-

ENANTIOMER -> RACEMATE

Amount:


					CLX07A6ZIY

NORDEXFENFLURAMINE

ENANTIOMER -> RACEMATE

Amount:


					6E2Z4UWILI

5-HYDROXYTRYPTAMINE RECEPTOR 2B

OFF-TARGET->AGONIST

Comments:

We propose that preferential stimulation of valvular 5-HT2B receptors by norfenfluramine, ergot drugs, or 5-HT released from carcinoid tumors (with or without accompanying 5-HT2A receptor activation) may contribute to valvular fibroplasia in humans.

Qualification:

Ki

Amount:


					3005782T7P

NORFENFLURAMINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					403FO0NQG3

PARENT -> METABOLITE TOXIC

Comments:

Preferential stimulation of valvular 5-HT2B receptors by norfenfluramine, ergot drugs, or 5-HT released from carcinoid tumors (with or without accompanying 5-HT2A receptor activation) may contribute to valvular fibroplasia in humans.

Amount:


					2DS058H2CF

PARENT -> METABOLITE


					2DS058H2CF

PARENT -> METABOLITE TOXIC

Comments:

Responsible for

Interaction Type:

MAJOR

Amount:

Related Record Type Details


					037A9J3PSW

Norfenfluramine

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC