CGMP-DEPENDENT PROTEIN KINASE 1

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 19:31:30 GMT 2025` Edited by `admin` on `Tue Apr 01 19:31:30 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	0GTQ39868X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CGMP-DEPENDENT PROTEIN KINASE 1

Common Name

English

CGK1

Preferred Name

English

CGK1-ALPHA

Common Name

English

PRKGR1B

Common Name

English

PRKG1B

Common Name

English

CGKI

Common Name

English

PRKGR1A

Common Name

English

CGMP-DEPENDENT PROTEIN KINASE I

Common Name

English

PKG-1.ALPHA.

Common Name

English

Code System Code Type Description

EC (ENZYME CLASS)

EC 2.7.11.12

Created by admin on Tue Apr 01 19:31:30 GMT 2025 , Edited by admin on Tue Apr 01 19:31:30 GMT 2025

PRIMARY

UNIPROT

Q13976

Created by admin on Tue Apr 01 19:31:30 GMT 2025 , Edited by admin on Tue Apr 01 19:31:30 GMT 2025

PRIMARY

PHAROS

Q13976

Created by admin on Tue Apr 01 19:31:30 GMT 2025 , Edited by admin on Tue Apr 01 19:31:30 GMT 2025

PRIMARY

WIKIPEDIA

PRKG1

Created by admin on Tue Apr 01 19:31:30 GMT 2025 , Edited by admin on Tue Apr 01 19:31:30 GMT 2025

PRIMARY

FDA UNII

0GTQ39868X

Created by admin on Tue Apr 01 19:31:30 GMT 2025 , Edited by admin on Tue Apr 01 19:31:30 GMT 2025

PRIMARY

From	To
1_42	2_42

Related Record Type Details


					524Y3IB4HQ

INHIBITOR -> TARGET


					2DW6Y8OU16

RADIOLIGAND->TARGET


					GWH480321B

INHIBITOR -> TARGET

Comments:

PKG1.beta.

Interaction Type:

IN-VITRO

Qualification:

IC50

Amount:


					524Y3IB4HQ

INHIBITOR -> TARGET

Comments:

IC50(PRKG1.beta.)=69 nM

Interaction Type:

IN-VITRO

Qualification:

IC50

Amount:


					GR20O32F2J

NOP-46

LIGAND->BINDER


					GWH480321B

INHIBITOR -> TARGET

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_58] [2_58]		THREONINE		THREONINE PHOSPHATE	3L4WX7B1EI
AMINO ACID SUBSTITUTION	[1_514] [2_514]		THREONINE		THREONINE PHOSPHATE	3L4WX7B1EI
AMINO ACID SUBSTITUTION	[1_1] [2_1]		SERINE		N-ACETYLSERINE	W98518XGZ3

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL