SONIDEGIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H26F3N3O3
Molecular Weight	485.4981
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of SONIDEGIB

Structure Search

SMILES

C[C@H]1CN(C[C@@H](C)O1)C2=CC=C(NC(=O)C3=CC=CC(C4=CC=C(OC(F)(F)F)C=C4)=C3C)C=N2

InChI

InChIKey=VZZJRYRQSPEMTK-CALCHBBNSA-N

InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+

HIDE SMILES / InChI

Molecular Formula	C26H26F3N3O3
Molecular Weight	485.4981
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:19:25 UTC 2023` Edited by `admin` on `Fri Dec 15 19:19:25 UTC 2023`
Record UNII	0RLU3VTK5M
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SONIDEGIB

Official Name

English

(1,1'-BIPHENYL)-3-CARBOXAMIDE, N-(6-((2R,6S)-2,6-DIMETHYL-4-MORPHOLINYL)-3-PYRIDINYL)-2-METHYL-4'-(TRIFLUOROMETHOXY)-, REL-

Common Name

English

LDE 225

Code

English

sonidegib [INN]

Common Name

English

NVP-LDE225

Code

English

SONIDEGIB [USAN]

Common Name

English

Sonidegib [WHO-DD]

Common Name

English

NVP-LDE 225

Code

English

N-(6-((2R,6S)-2,6-DIMETHYLMORPHOLIN-4-YL)PYRIDIN-3-YL)-2-METHYL-4'-(TRIFLUOROMETHOXY)BIPHENYL-3-CARBOXAMIDE

Systematic Name

English

N-(6-((CIS-2,6-DIMETHYLMORPHOLIN-4-YL)-3-PYRIDYL)-2-METHYL-3-(4-(TRIFLUOROMETHOXY)PHENYL)BENZAMIDE

Common Name

English

LDE-225

Code

English

LDE225

Code

English

NVP-LDE-225

Code

English

ERISMODEGIB

Common Name

English

SONIDEGIB [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2189

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

WHO-ATC

L01XX48

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

NDF-RT

N0000184149

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

FDA ORPHAN DRUG

468814

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

Code System Code Type Description

LACTMED

Sonidegib

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

DAILYMED

0RLU3VTK5M

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

RXCUI

1659191

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

RxNorm

CHEBI

90863

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

IUPHAR

8199

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

NDF-RT

N0000184148

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

Smoothened Receptor Antagonists [MoA]

ChEMBL

CHEMBL2105737

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

DRUG BANK

DB09143

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

CAS

956697-53-3

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

SMS_ID

100000145390

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

DRUG CENTRAL

5008

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

WIKIPEDIA

SONIDEGIB

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

EU-Orphan Drug

EU/3/09/697(WITHDRAWN)

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

Treatment of naevoid basal-cell carcinoma syndrome (Gorlin syndrome) 24/11/2009 Withdrawn

FDA UNII

0RLU3VTK5M

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

EPA CompTox

DTXSID50100933

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

MERCK INDEX

m11843

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

NCI_THESAURUS

C82385

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

PUBCHEM

24775005

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

USAN

YY-63

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

INN

9394

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

EVMPD

SUB123432

Created by admin on Fri Dec 15 19:19:25 UTC 2023 , Edited by admin on Fri Dec 15 19:19:25 UTC 2023

PRIMARY

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Comments:

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Amount:


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SONIDEGIB

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC