FIDEXABAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H24F2N6O5
Molecular Weight	526.4921
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(CC(O)=O)C1=C(F)C(OC2=CC(=CC=C2)C3=NCCN3C)=NC(OC4=C(O)C=CC(=C4)C(N)=N)=C1F

InChI

InChIKey=NPNSVNGQJGRSNR-UHFFFAOYSA-N

InChI=1S/C25H24F2N6O5/c1-32-9-8-30-23(32)14-4-3-5-15(10-14)37-24-19(26)21(33(2)12-18(35)36)20(27)25(31-24)38-17-11-13(22(28)29)6-7-16(17)34/h3-7,10-11,34H,8-9,12H2,1-2H3,(H3,28,29)(H,35,36)

HIDE SMILES / InChI

Molecular Formula	C25H24F2N6O5
Molecular Weight	526.4921
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10813384 | https://www.ncbi.nlm.nih.gov/pubmed/11740955

FIDEXABAN is a potent inhibitor of coagulation factor Xa with anticoagulant activity. Like other factor Xa inhibitors, it prevents thrombus formation.

Originator

Approval Year

PubMed

Title	Date	PubMed
Human in vitro pharmacodynamic profile of the selective Factor Xa inhibitor ZK-807834 (CI-1031).	2002-02-15	12031830
The antithrombotic effects of CI-1031 (ZK-807834) and enoxaparin in a canine electrolytic injury model of arterial and venous thrombosis.	2001-12-07	11740955
FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834.	2001-08-15	11562339
A novel synthetic inhibitor of factor Xa decreases early reocclusion and improves 24-h patency after coronary fibrinolysis in dogs.	2001-02	11160645
Effects of ZK-807834, a novel inhibitor of factor Xa, on arterial and venous thrombosis in rabbits.	2000-05	10813384

Patents

Sample Use Guides

In Vitro Use Guide

Fidexaban (ZK-807834) in the range of 0.3-0.5 microM prolonged prothrombin time and activated partial thromboplastin time twofold without affecting thrombin time. ZK-807834 inhibited Factor Xa in clot-bound prothrombinase with an average IC50 of 10+/-7 (S.D.) nM.

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:13:52 GMT 2025` Edited by `admin` on `Wed Apr 02 09:13:52 GMT 2025`
Record UNII	10NHF3008V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CI-1031

Preferred Name

English

FIDEXABAN

Official Name

English

ZK807834

Code

English

ZK-807834

Code

English

fidexaban [INN]

Common Name

English

[[2-(5-Carbamimidoyl-2-hydroxyphenoxy)-3,5-difluoro-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]methylamino]acetic acid

Systematic Name

English

FIDEXABAN [USAN]

Common Name

English

GLYCINE, N-(2-(5-(AMINOIMINOMETHYL)-2-HYDROXYPHENOXY)-6-(3-(4,5-DIHYDRO-1-METHYL-1H-IMIDAZOL-2-YL)PHENOXY)-3,5-DIFLUORO-4-PYRIDINYL)-N-METHYL-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C263