RINETERKIB

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H27BrF3N5O2
Molecular Weight	578.424
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC[C@@H](NC(=O)C1=CC=C(C=C1F)C2=C(N)N=CC(=N2)[C@H]3CC[C@H](O)[C@@H](F)C3)C4=CC(Br)=CC(F)=C4

InChI

InChIKey=YFCIFWOJYYFDQP-PTWZRHHISA-N

InChI=1S/C26H27BrF3N5O2/c1-32-11-21(15-6-16(27)10-17(28)7-15)35-26(37)18-4-2-14(9-19(18)29)24-25(31)33-12-22(34-24)13-3-5-23(36)20(30)8-13/h2,4,6-7,9-10,12-13,20-21,23,32,36H,3,5,8,11H2,1H3,(H2,31,33)(H,35,37)/t13-,20-,21+,23-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C26H27BrF3N5O2
Molecular Weight	578.424
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

C_max

Value	Dose	Co-administered	Analyte	Population
972 ng/mL CLINICAL TRIAL https://clinicaltrials.gov/study/NCT02711345	200 mg 1 times / day multiple, oral dose: 200 mg route of administration: Oral experiment type: MULTIPLE co-administered:		RINETERKIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
494 ng/mL CLINICAL TRIAL https://clinicaltrials.gov/study/NCT02711345	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:		RINETERKIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
14600 ng × h/mL CLINICAL TRIAL https://clinicaltrials.gov/study/NCT02711345	200 mg 1 times / day multiple, oral dose: 200 mg route of administration: Oral experiment type: MULTIPLE co-administered:		RINETERKIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
16.8 h CLINICAL TRIAL https://clinicaltrials.gov/study/NCT02711345	200 mg 1 times / day multiple, oral dose: 200 mg route of administration: Oral experiment type: MULTIPLE co-administered:		RINETERKIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:13:01 GMT 2025` Edited by `admin` on `Mon Mar 31 23:13:01 GMT 2025`
Record UNII	15KFN616FK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RINETERKIB

Official Name

English

BENZAMIDE, 4-(3-AMINO-6-((1S,3S,4S)-3-FLUORO-4-HYDROXYCYCLOHEXYL)-2-PYRAZINYL)-N-((1S)-1-(3-BROMO-5-FLUOROPHENYL)-2-(METHYLAMINO)ETHYL)-2-FLUORO-

Preferred Name

English

4-(3-AMINO-6-((1S,3S,4S)-3-FLUORO-4-HYDROXYCYCLOHEXYL)-2-PYRAZINYL)-N-((1S)-1-(3-BROMO-5-FLUOROPHENYL)-2-(METHYLAMINO)ETHYL)-2-FLUOROBENZAMIDE

Systematic Name

English

Rineterkib [WHO-DD]

Common Name

English

rineterkib [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000027616