TELRATOLIMOD

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Details

Stereochemistry	ACHIRAL
Molecular Formula	C36H59N5O2
Molecular Weight	593.886
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TELRATOLIMOD

Structure Search

SMILES

CCCCCCCCCCCCCCCCCC(=O)NCCCCON1C(CCCC)=NC2=C1C3=C(C=CC=C3)N=C2N

InChI

InChIKey=RRTPWQXEERTRRK-UHFFFAOYSA-N

InChI=1S/C36H59N5O2/c1-3-5-7-8-9-10-11-12-13-14-15-16-17-18-19-27-33(42)38-28-22-23-29-43-41-32(26-6-4-2)40-34-35(41)30-24-20-21-25-31(30)39-36(34)37/h20-21,24-25H,3-19,22-23,26-29H2,1-2H3,(H2,37,39)(H,38,42)

HIDE SMILES / InChI

Molecular Formula	C36H59N5O2
Molecular Weight	593.886
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 02:53:13 UTC 2023` Edited by `admin` on `Sat Dec 16 02:53:13 UTC 2023`
Record UNII	16598XQ2BT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TELRATOLIMOD

Official Name

English

N-(4-((4-AMINO-2-BUTYL-1H-IMIDAZO(4,5-C)QUINOLIN-1-YL)OXY)BUTYL)OCTADECANAMIDE

Systematic Name

English

3M-052

Code

English

Telratolimod [WHO-DD]

Common Name

English

OCTADECANAMIDE, N-(4-((4-AMINO-2-BUTYL-1H-IMIDAZO(4,5-C)QUINOLIN-1-YL)OXY)BUTYL)-

Systematic Name

English

telratolimod [INN]

Common Name

English

MEDI9197

Code

English

MEDI-9197

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2139

Created by admin on Sat Dec 16 02:53:13 UTC 2023 , Edited by admin on Sat Dec 16 02:53:13 UTC 2023

Code System Code Type Description

FDA UNII

16598XQ2BT

Created by admin on Sat Dec 16 02:53:13 UTC 2023 , Edited by admin on Sat Dec 16 02:53:13 UTC 2023

PRIMARY

CAS

1359993-59-1

Created by admin on Sat Dec 16 02:53:13 UTC 2023 , Edited by admin on Sat Dec 16 02:53:13 UTC 2023

PRIMARY

EVMPD

SUB184743

Created by admin on Sat Dec 16 02:53:13 UTC 2023 , Edited by admin on Sat Dec 16 02:53:13 UTC 2023

PRIMARY

INN

10781

Created by admin on Sat Dec 16 02:53:13 UTC 2023 , Edited by admin on Sat Dec 16 02:53:13 UTC 2023

PRIMARY

PUBCHEM

56833311

Created by admin on Sat Dec 16 02:53:13 UTC 2023 , Edited by admin on Sat Dec 16 02:53:13 UTC 2023

PRIMARY

NCI_THESAURUS

C124653

Created by admin on Sat Dec 16 02:53:13 UTC 2023 , Edited by admin on Sat Dec 16 02:53:13 UTC 2023

PRIMARY

SMS_ID

100000170639

Created by admin on Sat Dec 16 02:53:13 UTC 2023 , Edited by admin on Sat Dec 16 02:53:13 UTC 2023

PRIMARY

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					16598XQ2BT

ACTIVE MOIETY

Comments:

Direct activation of innate immune cells with anti-tumor activity was observed, as was a reduction in the immunosuppressive local environment. 3M-052 also induces the accumulation of mononuclear phagocytes concomitant with the induction of histologically established tumor liquifactive necrosis. Moreover, 3M-052 induces antitumor activity when injected into tumors but not when injected distal from tumors. These findings are based on inhibition of tumor growth and increased long-term survival. 3M-052 is under consideration for clinical use in patients with cancers suitable for intratumoral therapy and as being evaluated as a cancer vaccine adjuvant.