SACUBITRIL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H29NO5
Molecular Weight	411.4908
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of SACUBITRIL

Structure Search

SMILES

CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(O)=O

InChI

InChIKey=PYNXFZCZUAOOQC-UTKZUKDTSA-N

InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C24H29NO5
Molecular Weight	411.4908
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 06:55:51 UTC 2023` Edited by `admin` on `Sat Dec 16 06:55:51 UTC 2023`
Record UNII	17ERJ0MKGI
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SACUBITRIL

Official Name

English

AHU-377

Code

English

SACUBITRIL [JAN]

Common Name

English

SACUBITRIL COMPONENT OF ENTRESTO

Brand Name

English

SACUBITRIL [MI]

Common Name

English

ENTRESTO COMPONENT SACUBITRIL

Brand Name

English

(2R,4S)-5-(BIPHENYL-4-YL)-4-((3-CARBOXYPROPIONYL)AMINO)-2-METHYLPENTANOIC ACID ETHYL ESTER

Systematic Name

English

SACUBITRIL [USAN]

Common Name

English

sacubitril [INN]

Common Name

English

SACUBITRIL [ORANGE BOOK]

Common Name

English

AHU377

Code

English

Sacubitril [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C270

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

WHO-ATC

C09DX04

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

Code System Code Type Description

EVMPD

SUB170848

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

PRIMARY

MERCK INDEX

m11856

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

PRIMARY

WIKIPEDIA

Sacubitril

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

PRIMARY

USAN

BC-54

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

PRIMARY

DAILYMED

17ERJ0MKGI

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

PRIMARY

LACTMED

Sacubitril

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

PRIMARY

DRUG CENTRAL

5012

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

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NCI_THESAURUS

C152281

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

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CAS

149709-62-6

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

PRIMARY

RXCUI

1656328

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

PRIMARY

RxNorm

EPA CompTox

DTXSID20164370

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

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FDA UNII

17ERJ0MKGI

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

PRIMARY

IUPHAR

7857

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

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SMS_ID

100000159950

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

PRIMARY

DRUG BANK

DB09292

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

PRIMARY

INN

9819

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

PRIMARY

PUBCHEM

9811834

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

PRIMARY

ChEMBL

CHEMBL3137301

Created by admin on Sat Dec 16 06:55:52 UTC 2023 , Edited by admin on Sat Dec 16 06:55:52 UTC 2023

PRIMARY

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SACUBITRIL SODIUM

SALT/SOLVATE -> PARENT

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METABOLIC ENZYME -> SUBSTRATE

Amount:


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PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


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SACUBITRIL VALSARTAN SODIUM HYDRATE

SALT/SOLVATE -> PARENT

Amount:


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SACUBITRIL CALCIUM

SALT/SOLVATE -> PARENT

Amount:

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METABOLITE ACTIVE -> PRODRUG

Amount:

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ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ORAL BIOAVAILABILITY	PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION

Biological Half-life	PHARMACOKINETIC