U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 16:33:54 GMT 2025
Edited
by admin
on Tue Apr 01 16:33:54 GMT 2025
Protein Type ENZYME
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
HPN66MJEK8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LIVER CARBOXYLESTERASE 1
Common Name English
CES1
Preferred Name English
RETINYL ESTER HYDROLASE
Common Name English
SERINE ESTERASE 1
Common Name English
MONOCYTE/MACROPHAGE SERINE ESTERASE
Common Name English
TRIACYLGLYCEROL HYDROLASE
Common Name English
SES1
Common Name English
EGASYN
Common Name English
COCAINE CARBOXYLESTERASE
Common Name English
HMSE
Common Name English
METHYLUMBELLIFERYL-ACETATE DEACETYLASE
Common Name English
ACYL-COENZYME A:CHOLESTEROL ACYLTRANSFERASE
Common Name English
Code System Code Type Description
WIKIPEDIA
Carboxylesterase 1
Created by admin on Tue Apr 01 16:33:54 GMT 2025 , Edited by admin on Tue Apr 01 16:33:54 GMT 2025
PRIMARY
EC (ENZYME CLASS)
EC 3.1.1.1
Created by admin on Tue Apr 01 16:33:54 GMT 2025 , Edited by admin on Tue Apr 01 16:33:54 GMT 2025
PRIMARY
UNIPROT
P23141
Created by admin on Tue Apr 01 16:33:54 GMT 2025 , Edited by admin on Tue Apr 01 16:33:54 GMT 2025
PRIMARY
FDA UNII
HPN66MJEK8
Created by admin on Tue Apr 01 16:33:54 GMT 2025 , Edited by admin on Tue Apr 01 16:33:54 GMT 2025
PRIMARY
PHAROS
P23141
Created by admin on Tue Apr 01 16:33:54 GMT 2025 , Edited by admin on Tue Apr 01 16:33:54 GMT 2025
PRIMARY
From To
1_70 1_99
1_257 1_268
2_70 2_99
2_257 2_268
3_70 3_99
3_257 3_268
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_62
N 2_62
N 3_62
Related Record Type Details
Structure of SACUBITRIL
SUBSTRATE -> METABOLIC ENZYME
Structure of OSELTAMIVIR
SUBSTRATE -> METABOLIC ENZYME
Structure of ENALAPRIL
SUBSTRATE -> METABOLIC ENZYME
Structure of REMDESIVIR
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of DABIGATRAN
SUBSTRATE -> METABOLIC ENZYME
Structure of EDOXABAN
SUBSTRATE -> METABOLIC ENZYME
Structure of PSI-7976
SUBSTRATE -> METABOLIC ENZYME
IN-VITRO
RATE
Structure of 2-OXO-CLOPIDOGREL
SUBSTRATE -> METABOLIC ENZYME
Structure of SOFOSBUVIR
SUBSTRATE -> METABOLIC ENZYME
IN-VITRO
RATE
Structure of Selexipag
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of VILAZODONE
SUBSTRATE -> METABOLIC ENZYME
Structure of LIDOCAINE
SUBSTRATE -> METABOLIC ENZYME
Structure of TEFINOSTAT
SUBSTRATE -> METABOLIC ENZYME
Structure of Irinotecan
SUBSTRATE -> METABOLIC ENZYME
CES1A1
Structure of TP-0473292
SUBSTRATE -> METABOLIC ENZYME
Structure of USISTAPIDE
SUBSTRATE -> METABOLIC ENZYME
Structure of CLOPIDOGREL
SUBSTRATE -> METABOLIC ENZYME
Structure of IMIDAPRIL
SUBSTRATE -> METABOLIC ENZYME
Structure of RAMIPRIL
SUBSTRATE -> METABOLIC ENZYME
Vmax
Structure of TRANDOLAPRIL
SUBSTRATE -> METABOLIC ENZYME
Structure of TENOFOVIR ALAFENAMIDE
SUBSTRATE -> METABOLIC ENZYME
Structure of PD-128042
INHIBITOR -> TARGET
PARTIAL AGONIST
POTENCY
Structure of METHYLPHENIDATE
SUBSTRATE -> METABOLIC ENZYME
Structure of PF-06815345
SUBSTRATE -> METABOLIC ENZYME
Structure of QUINAPRIL
SUBSTRATE -> METABOLIC ENZYME
Structure of PACTIMIBE
INHIBITOR -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_363] [2_363] [3_363] SITE_SPECIFIC DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL
NIH
NCATS
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