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Details

Stereochemistry ACHIRAL
Molecular Formula C14H19Cl2NO2
Molecular Weight 304.212
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLORAMBUCIL

SMILES

OC(=O)CCCC1=CC=C(C=C1)N(CCCl)CCCl

InChI

InChIKey=JCKYGMPEJWAADB-UHFFFAOYSA-N
InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

HIDE SMILES / InChI
Molecular Formula C14H19Cl2NO2
Molecular Weight 304.212
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
123738
Substance Class Chemical
Created
by admin
on Fri Dec 15 14:58:24 UTC 2023
Edited
by admin
on Fri Dec 15 14:58:24 UTC 2023
Record UNII
18D0SL7309
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHLORAMBUCIL
EP   HSDB   INN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INN  
Official Name English
CB-1348
Code English
CHLORAMBUCIL [JAN]
Common Name English
CHLORAMBUCIL [EP MONOGRAPH]
Common Name English
CHLORAMBUCIL [IARC]
Common Name English
4-(P-(BIS(2-CHLOROETHYL)AMINO)PHENYL)BUTYRIC ACID
Common Name English
CHLORAMBUCILUM [WHO-IP LATIN]
Common Name English
Chlorambucil [WHO-DD]
Common Name English
AMBOCHLORIN
Common Name English
LEUKERAN
Brand Name English
NSC-3088
Code English
CHLORAMBUCIL [VANDF]
Common Name English
ECLORIL
Common Name English
BENZENEBUTANOIC ACID, 4-(BIS(2-CHLOROETHYL)AMINO)-
Common Name English
LYMPHOLYSIN
Common Name English
CHLORAMBUCIL [MART.]
Common Name English
CHLORAMBUCIL [HSDB]
Common Name English
CHLORAMBUCIL [WHO-IP]
Common Name English
NCI-3088
Code English
CHLORAMBUCIL [USP-RS]
Common Name English
chlorambucil [INN]
Common Name English
CHLORAMBUCIL [ORANGE BOOK]
Common Name English
CHLORAMBUCIL [MI]
Common Name English
CHLORAMBUCIL [USP MONOGRAPH]
Common Name English
Classification Tree Code System Code
LIVERTOX NBK548207
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
NDF-RT N0000175558
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
NDF-RT N0000000236
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
NCI_THESAURUS C697
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
WHO-VATC QL01AA02
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
WHO-ATC L01AA02
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
WHO-ESSENTIAL MEDICINES LIST 8.2
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
Code System Code Type Description
WIKIPEDIA
CHLORAMBUCIL
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
EVMPD
SUB06172MIG
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
CAS
305-03-3
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
MERCK INDEX
m3343
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY Merck Index
EPA CompTox
DTXSID7020263
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
ECHA (EC/EINECS)
206-162-0
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
RS_ITEM_NUM
1106001
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
IUPHAR
7143
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
ChEMBL
CHEMBL515
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
HSDB
3026
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
FDA UNII
18D0SL7309
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
CHEBI
28830
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
DRUG BANK
DB00291
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
RXCUI
2346
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY RxNorm
PUBCHEM
2708
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
INN
603
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
NSC
3088
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
DAILYMED
18D0SL7309
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
NCI_THESAURUS
C362
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
MESH
D002699
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
SMS_ID
100000081577
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
DRUG CENTRAL
588
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
CHLORAMBUCIL
Created by admin on Fri Dec 15 14:58:24 UTC 2023 , Edited by admin on Fri Dec 15 14:58:24 UTC 2023
PRIMARY Description: A white or almost white, crystalline or slightly granular powder. Solubility: Practically insoluble in water; freely soluble in ethanol (~750 g/l) TS and acetone R. Category: Cytotoxic drug. Storage: Chlorambucil should be kept in a well-closed container, protected from light. Additional information: CAUTION: Chlorambucil must be handled with care, avoiding contact with the skin and inhalation of airborne particles. Definition: Chlorambucil contains not less than 98.0% and not more than 101.0% of C14H19Cl2NO2, calculated with reference to the anhydrous substance.
Related Record Type Details
Structure of CHLORAMBUCIL
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> SUBSTRATE
Structure of CHLORAMBUCIL
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
USP
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
Related Record Type Details
Structure of N,N-BIS(2-CHLOROETHYL)-P-AMINOPHENYLACETIC ACID
METABOLITE ACTIVE -> PARENT
Has antineoplastic activity
Related Record Type Details
Structure of ORTHO-CHLORAMBUCIL
IMPURITY -> PARENT
Structure of CHLORAMBUCIL TRIMER ESTER
IMPURITY -> PARENT
Structure of HYDROXY CHLORAMBUCIL
IMPURITY -> PARENT
Structure of CHLORAMBUCIL CHLOROETHYL ESTER
IMPURITY -> PARENT
Structure of 4-(4-((2-((BIS(2-CHLOROETHOXY)PHOSPHORYL)OXY)ETHYL)(2-CHLOROETHYL)AMINO)PHENYL)BUTANOIC ACID
IMPURITY -> PARENT
Structure of MONOCHLOROETHYL CHLORAMBUCIL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of CHLORAMBUCIL DIMER ESTER
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of CHLORAMBUCIL
ACTIVE MOIETY
A white or almost white, crystalline or slightly granular powder.
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
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