BETAZOLE

US Previously Marketed

First approved in 1954

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H9N3
Molecular Weight	111.1451
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NCCC1=NNC=C1

InChI

InChIKey=JXDFEQONERDKSS-UHFFFAOYSA-N

InChI=1S/C5H9N3/c6-3-1-5-2-4-7-8-5/h2,4H,1,3,6H2,(H,7,8)

HIDE SMILES / InChI

Molecular Formula	C5H9N3
Molecular Weight	111.1451
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.hmdb.ca/metabolites/HMDB0014417 | https://www.ncbi.nlm.nih.gov/mesh/68001625

BETAZOLE is a histamine H2 receptor agonist used clinically to test gastric secretory function.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H2 receptor 46 Target ID: CHEMBL1941 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3661710 \| https://www.ncbi.nlm.nih.gov/pubmed/7316286	Agonist 2752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Stomach Diseases 2 Sources: http://drugcentral.org/drugcard/357 https://www.drugbank.ca/drugs/DB00272	Diagnostic		Approved 8583	Histalog Approved Use For use clinically to test gastric secretory function. Launch Date 1952

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
ALDH 8

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
ALDH 8	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/466870/	yes

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:59170	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:59170
eMolecules	31503597	https://www.emolecules.com/cgi-bin/more?vid=31503597
eMolecules	34962	https://www.emolecules.com/cgi-bin/more?vid=34962
MolPort	MolPort-001-787-387	https://www.molport.com/shop/molecule-link/MolPort-001-787-387
MolPort	MolPort-006-167-503	https://www.molport.com/shop/molecule-link/MolPort-006-167-503
ZINC	ZINC000000001028	http://zinc15.docking.org/substances/ZINC000000001028

PubMed

Title	Date	PubMed
Gastric secretory and hormonal patterns in end-stage chagasic achalasia.	2009	19302218
Gastric analysis with fractional test meals (ethanol, caffeine, and peptone meal), augmented histamine or pentagastrin tests, and gastric pH recording.	2003-12	15075465
The effect of intravenous histalog on gastric secretion in man.	1967-11	6057052
Detection of achlorhydria by tubeless gastric analysis with betazole hydrochloride as the gastric stimulant.	1959-09-10	14444529

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:46:06 GMT 2025` Edited by `admin` on `Mon Mar 31 17:46:06 GMT 2025`
Record UNII	1C065P542O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMETAZOLE

Preferred Name

English

BETAZOLE

Official Name

English

Betazole [WHO-DD]

Common Name

English

1H-PYRAZOLE-3-ETHANAMINE

Systematic Name

English

BETAZOLE [VANDF]

Common Name

English

2-(1H-PYRAZOL-3-YL)ETHANAMINE

Systematic Name

English

betazole [INN]

Common Name

English

BETAZOLE [MI]

Common Name

English

3-(2-AMINOETHYL)PYRAZOLE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1937