Coramitug

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 23:20:53 GMT 2025` Edited by `admin` on `Tue Apr 01 23:20:53 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	1D57NC901Z
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Gamma1 heavy chain (1-454) [VH (Mus musculus IGHV5-12-2*01 (92.9%) -(IGHD) -IGHJ4*01 (84.6%) S123>L (119), CDR-IMGT [8.8.17] (26-33.51-58.97-113)) (1-124) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1CH1 R120, E12, M14 (CH1 R120 (221)(125-222), hinge 1-15 (

Preferred Name

English

Coramitug

Official Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens TTR (transthyretin) misfolded], monoclonal antibody

Common Name

English

coramitug [INN]

Common Name

English

Immunoglobulin G1, anti-(human transthyretin) (human-Mus musculus monoclonal PRX004 ?1-chain), disulfide with human-Mus musculus monoclonal PRX004 ?-chain, dimer

Common Name

English

Code System Code Type Description

SMS_ID

300000039928

Created by admin on Tue Apr 01 23:20:53 GMT 2025 , Edited by admin on Tue Apr 01 23:20:53 GMT 2025

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FDA UNII

1D57NC901Z

Created by admin on Tue Apr 01 23:20:53 GMT 2025 , Edited by admin on Tue Apr 01 23:20:53 GMT 2025

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INN

12646

Created by admin on Tue Apr 01 23:20:53 GMT 2025 , Edited by admin on Tue Apr 01 23:20:53 GMT 2025

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CAS

2626841-92-5

Created by admin on Tue Apr 01 23:20:53 GMT 2025 , Edited by admin on Tue Apr 01 23:20:53 GMT 2025

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NCI_THESAURUS

C203146

Created by admin on Tue Apr 01 23:20:53 GMT 2025 , Edited by admin on Tue Apr 01 23:20:53 GMT 2025

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From	To
2_374	2_432
1_374	1_432
1_22	1_96
2_22	2_96
2_151	2_207
2_227	4_219
2_268	2_328
1_151	1_207
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199
1_227	3_219
1_233	2_233
1_236	2_236
1_268	1_328

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_52
N	1_304
N	2_52
N	2_304

Related Record Type Details


					2COU0B578R

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					1D57NC901Z

Coramitug

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_454] [2_454]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL