DAPAGLIFLOZIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H25ClO6
Molecular Weight	408.873
Optical Activity	( + )
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DAPAGLIFLOZIN

Structure Search

SMILES

CCOC1=CC=C(CC2=C(Cl)C=CC(=C2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C1

InChI

InChIKey=JVHXJTBJCFBINQ-ADAARDCZSA-N

InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C21H25ClO6
Molecular Weight	408.873
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:55:11 UTC 2023` Edited by `admin` on `Fri Dec 15 16:55:11 UTC 2023`
Record UNII	1ULL0QJ8UC
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DAPAGLIFLOZIN

Official Name

English

DAPAGLIFLOZIN [MI]

Common Name

English

QTERNMET XR COMPONENT DAPAGLIFLOZIN

Brand Name

English

LYN-045

Code

English

Dapagliflozin [WHO-DD]

Common Name

English

DAPAGLIFLOZIN COMPONENT QTERNMET

Brand Name

English

QTERNMET COMPONENT DAPAGLIFOZIN

Common Name

English

(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Systematic Name

English

DAPAGLIFLOZIN [USAN]

Common Name

English

DAPAGLIFLOZIN [ORANGE BOOK]

Common Name

English

D-GLUCITOL, 1,5-ANHYDRO-1-C-(4-CHLORO-3-((4-ETHOXYPHENYL)METHYL)PHENYL)-, (1S)-

Systematic Name

English

DAPAGLIFLOZIN COMPONENT OF QTERNMET XR

Brand Name

English

dapagliflozin [INN]

Common Name

English

DAPAGLIFLOZIN [VANDF]

Common Name

English

BMS-512148

Code

English

Classification Tree Code System Code

WHO-ATC

A10BD25

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

NDF-RT

N0000187059

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

WHO-ATC

A10BK01

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

NCI_THESAURUS

C98083

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

WHO-VATC

QA10BD15

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

WHO-ATC

A10BX09

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

WHO-ATC

A10BD15

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

WHO-VATC

QA10BX09

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

WHO-ATC

A10BD21

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

Code System Code Type Description

DAILYMED

1ULL0QJ8UC

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

EVMPD

SUB31650

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

NDF-RT

N0000187058

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

Sodium-Glucose Transporter 2 Inhibitors [MoA]

USAN

SS-83

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

WIKIPEDIA

Dapagliflozin

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

CHEBI

85078

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

DRUG BANK

DB06292

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

EPA CompTox

DTXSID20905104

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

RXCUI

1488564

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

RxNorm

DRUG CENTRAL

4304

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

LACTMED

Dapagliflozin

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

MERCK INDEX

m4086

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

Merck Index

MESH

C529054

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

ChEMBL

CHEMBL429910

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

NCI_THESAURUS

C78126

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

FDA UNII

1ULL0QJ8UC

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

IUPHAR

4594

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

CAS

461432-26-8

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

PUBCHEM

9887712

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

SMS_ID

100000124178

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

INN

8886

Created by admin on Fri Dec 15 16:55:11 UTC 2023 , Edited by admin on Fri Dec 15 16:55:11 UTC 2023

PRIMARY

Related Record Type Details


					U289305BKG

DAPAGLIFLOZIN 2,3-BUTANEDIOL MONOHYDRATE

SOLVATE->ANHYDROUS


					887K2391VH

DAPAGLIFLOZIN PROPANEDIOL

SOLVATE->ANHYDROUS

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE

Amount:


					887K2391VH

DAPAGLIFLOZIN PROPANEDIOL

SALT/SOLVATE -> PARENT

Amount:


					4AKF24FA4C

DAPAGLIFLOZIN PROPANEDIOL ANHYDROUS

SOLVATE->ANHYDROUS

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					Q54R5GG9QQ

Dapagliflozin diproline

SALT/SOLVATE -> PARENT

Amount:


					1ULL0QJ8UC

EXCRETED UNCHANGED

Qualification:

URINE

Amount:


					4AKF24FA4C

DAPAGLIFLOZIN PROPANEDIOL ANHYDROUS

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					X42P3B148J

DAPAGLIFLOZIN 3-O-GLUCURONIDE

METABOLITE INACTIVE -> PARENT

Interaction Type:

MAJOR

Qualification:

FECAL; PLASMA; URINE

Amount:


					X42P3B148J

DAPAGLIFLOZIN 3-O-GLUCURONIDE

METABOLITE INACTIVE -> PARENT

Interaction Type:

MAJOR

Amount:


					00K1K06ADY

METABOLITE -> PARENT

Interaction Type:

MINOR

Amount:

Related Record Type Details


					1ULL0QJ8UC

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION DOSE FASTED STATE

Biological Half-life	PHARMACOKINETIC