TUCATINIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H24N8O2
Molecular Weight	480.5212
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TUCATINIB

Structure Search

SMILES

CC1=C(OC2=CC3=NC=NN3C=C2)C=CC(NC4=NC=NC5=C4C=C(NC6=NC(C)(C)CO6)C=C5)=C1

InChI

InChIKey=SDEAXTCZPQIFQM-UHFFFAOYSA-N

InChI=1S/C26H24N8O2/c1-16-10-17(5-7-22(16)36-19-8-9-34-23(12-19)28-15-30-34)31-24-20-11-18(4-6-21(20)27-14-29-24)32-25-33-26(2,3)13-35-25/h4-12,14-15H,13H2,1-3H3,(H,32,33)(H,27,29,31)

HIDE SMILES / InChI

Molecular Formula	C26H24N8O2
Molecular Weight	480.5212
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:31:36 UTC 2023` Edited by `admin` on `Sat Dec 16 09:31:36 UTC 2023`
Record UNII	234248D0HH
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TUCATINIB

Official Name

English

TUKYSA

Brand Name

English

MK-7119

Code

English

TUCATINIB [USAN]

Common Name

English

IRBINITINIB

Common Name

English

ONT-380

Code

English

TUCATINIB [ORANGE BOOK]

Common Name

English

4,6-QUINAZOLINEDIAMINE, N6-(4,5-DIHYDRO-4,4-DIMETHYL-2-OXAZOLYL)-N4-(3-METHYL-4-((1,2,4)TRIAZOLO(1,5-A)PYRIDIN-7-YLOXY)PHENYL)-

Systematic Name

English

tucatinib [INN]

Common Name

English

TUCATINIB [MI]

Common Name

English

Tucatinib [WHO-DD]

Common Name

English

ARRY-380

Code

English

N6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]quinazoline-4,6-diamine

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2167

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

FDA ORPHAN DRUG

570716

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

FDA ORPHAN DRUG

603217

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

FDA ORPHAN DRUG

571216

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

Code System Code Type Description

WIKIPEDIA

Tucatinib

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

ChEMBL

CHEMBL3545380

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

INN

9997

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

USAN

DE-115

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

CAS

937263-43-9

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

NCI_THESAURUS

C77896

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

DRUG CENTRAL

5389

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

EPA CompTox

DTXSID601027958

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

EVMPD

SUB177913

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

DAILYMED

234248D0HH

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

RXCUI

2361285

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

MERCK INDEX

m12198

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

SMS_ID

100000163588

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

FDA UNII

234248D0HH

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

PUBCHEM

51039094

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

DRUG BANK

DB11652

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

LACTMED

Tucatinib

Created by admin on Sat Dec 16 09:31:36 UTC 2023 , Edited by admin on Sat Dec 16 09:31:36 UTC 2023

PRIMARY

Related Record Type Details


					76UB6O122H

ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2

TRANSPORTER -> SUBSTRATE

Amount:


					CDZ29KT2FT

TUCATINIB HEMIETHANOLATE

SOLVATE->ANHYDROUS


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> INHIBITOR

Interaction Type:

TIME-DEPENDENT INHIBITION


					L0423Z5LDW

CYTOCHROME P450 2C8

METABOLIC ENZYME -> INHIBITOR

Interaction Type:

REVERSIBLE

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> INHIBITOR

Interaction Type:

REVERSIBLE


					234248D0HH

TUCATINIB

EXCRETED UNCHANGED

Qualification:

FECAL

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					L0423Z5LDW

CYTOCHROME P450 2C8

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

MAJOR


					CDZ29KT2FT

TUCATINIB HEMIETHANOLATE

SALT/SOLVATE -> PARENT

Amount:


					7J9Y28299R

RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2

TARGET -> INHIBITOR

Interaction Type:

SELECTIVE

Qualification:

Ki

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Related Record Type Details


					234248D0HH

TUCATINIB

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC