LASOFOXIFENE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C28H31NO2
Molecular Weight	413.5512
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LASOFOXIFENE

Structure Search

SMILES

OC1=CC=C2[C@H]([C@H](CCC2=C1)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4

InChI

InChIKey=GXESHMAMLJKROZ-IAPPQJPRSA-N

InChI=1S/C28H31NO2/c30-24-11-15-27-23(20-24)10-14-26(21-6-2-1-3-7-21)28(27)22-8-12-25(13-9-22)31-19-18-29-16-4-5-17-29/h1-3,6-9,11-13,15,20,26,28,30H,4-5,10,14,16-19H2/t26-,28+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C28H31NO2
Molecular Weight	413.5512
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:03:54 UTC 2023` Edited by `admin` on `Fri Dec 15 16:03:54 UTC 2023`
Record UNII	337G83N988
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LASOFOXIFENE

Official Name

English

Lasofoxifene [WHO-DD]

Common Name

English

LASOFOXIFENE [MI]

Common Name

English

LASOFOXIFENE [MART.]

Common Name

English

LASOFOXIFENE [EMA EPAR]

Common Name

English

(-)-CIS-5,6,7,8-TETRAHYDRO-6-PHENYL-5-(P-(2-(1-PYRROLIDINYL)ETHOXY)PHENYL)-2-NAPHTHOL

Common Name

English

lasofoxifene [INN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QG03XC03

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

NCI_THESAURUS

C1821

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

WHO-ATC

G03XC03

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

Code System Code Type Description

CHEBI

135938

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

PRIMARY

SMS_ID

100000092767

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

PRIMARY

PUBCHEM

216416

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

PRIMARY

DRUG CENTRAL

4308

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

PRIMARY

EPA CompTox

DTXSID50171037

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

PRIMARY

DRUG BANK

DB06202

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

PRIMARY

CAS

180916-16-9

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

PRIMARY

NCI_THESAURUS

C80679

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

PRIMARY

FDA UNII

337G83N988

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

PRIMARY

MERCK INDEX

m6700

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

PRIMARY

Merck Index

WIKIPEDIA

Lasofoxifene

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

PRIMARY

EVMPD

SUB27754

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

PRIMARY

INN

7875

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

PRIMARY

ChEMBL

CHEMBL328190

Created by admin on Fri Dec 15 16:03:55 UTC 2023 , Edited by admin on Fri Dec 15 16:03:55 UTC 2023

PRIMARY

Related Record Type Details


					85X09V2GSO

LASOFOXIFENE TARTRATE

SALT/SOLVATE -> PARENT


					S0025AG5ZT

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A10

METABOLIC ENZYME -> SUBSTRATE


					3318TFY23Q

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A9

METABOLIC ENZYME -> SUBSTRATE


					805SU96HKF

CYTOCHROME P450 3A5

METABOLIC ENZYME -> SUBSTRATE


					337G83N988

EXCRETED UNCHANGED

Qualification:

FECAL

Amount:


					IHQ709299P

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A3

METABOLIC ENZYME -> SUBSTRATE


					SIDP85PFD6

ESTROGEN RECEPTOR

TARGET -> AGONIST


					S5EY2C8G0B

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A8

METABOLIC ENZYME -> SUBSTRATE


					337G83N988

EXCRETED UNCHANGED

Qualification:

URINE

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					FGQ0BCJ2G9

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A6

METABOLIC ENZYME -> SUBSTRATE


					0RFO7VC96N

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1

METABOLIC ENZYME -> SUBSTRATE

Related Record Type Details


					FNT0UY50G8

1-(2-(4-((1R,2S)-1,2,3,4-TETRAHYDRO-6-HYDROXY-2-PHENYL-1-NAPHTHALENYL)PHENOXY)ETHYL)-2-PYRROLIDINONE

METABOLITE -> PARENT

Qualification:

FECAL

Amount:


					Z9K1Q76GZB

2-NAPHTHALENOL, 5,6,7,8-TETRAHYDRO-6-PHENYL-5-(4-(2-(1-PYRROLIDINYL)ETHOXY)PHENYL)-, 2-(HYDROGEN SULFATE), (5R,6S)-

METABOLITE -> PARENT

Qualification:

FECAL

Amount:


					GY8G45GVI4

(5R,6S)-5,6,7,8-TETRAHYDRO-6-PHENYL-5-(4-(2-(1-PYRROLIDINYL)ETHOXY)PHENYL)-2-NAPHTHALEN .BETA.-D-GLUCOPYRANOSIDURONIC ACID

METABOLITE -> PARENT

Qualification:

URINE

Amount:


					GY8G45GVI4

(5R,6S)-5,6,7,8-TETRAHYDRO-6-PHENYL-5-(4-(2-(1-PYRROLIDINYL)ETHOXY)PHENYL)-2-NAPHTHALEN .BETA.-D-GLUCOPYRANOSIDURONIC ACID

METABOLITE -> PARENT

Qualification:

PLASMA

Amount:

Related Record Type Details


					337G83N988

ACTIVE MOIETY