Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C29H37N3O3 |
| Molecular Weight | 475.6224 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCN(C)[C@H]1COC2=CC=CC=C2C3=C(C4CCCCC4)C5=C(C=C(C=C5)C(O)=O)N3C1
InChI
InChIKey=YQUCBFIQSJVCOR-JOCHJYFZSA-N
InChI=1S/C29H37N3O3/c1-30(2)15-16-31(3)22-18-32-25-17-21(29(33)34)13-14-23(25)27(20-9-5-4-6-10-20)28(32)24-11-7-8-12-26(24)35-19-22/h7-8,11-14,17,20,22H,4-6,9-10,15-16,18-19H2,1-3H3,(H,33,34)/t22-/m1/s1
| Molecular Formula | C29H37N3O3 |
| Molecular Weight | 475.6224 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| In vitro efficacy of approved and experimental antivirals against novel genotype 3 hepatitis C virus subgenomic replicons. | 2013-11 |
|
| Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase. | 2011-01-13 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Apr 01 16:25:49 GMT 2025
by
admin
on
Tue Apr 01 16:25:49 GMT 2025
|
| Record UNII |
3593C180JO
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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Preferred Name | English | ||
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| Code System | Code | Type | Description | ||
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3593C180JO
Created by
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DTXSID00237197
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admin on Tue Apr 01 16:25:49 GMT 2025 , Edited by admin on Tue Apr 01 16:25:49 GMT 2025
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886041-60-7
Created by
admin on Tue Apr 01 16:25:49 GMT 2025 , Edited by admin on Tue Apr 01 16:25:49 GMT 2025
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100000175842
Created by
admin on Tue Apr 01 16:25:49 GMT 2025 , Edited by admin on Tue Apr 01 16:25:49 GMT 2025
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49800096
Created by
admin on Tue Apr 01 16:25:49 GMT 2025 , Edited by admin on Tue Apr 01 16:25:49 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
TARGET ORGANISM->INHIBITOR |
Chimeric replicons containing different
NS5B genotype 2b.
EC50
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||
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TARGET ORGANISM->INHIBITOR |
Chimeric replicons containing different
NS5B genotype 2a.
EC50
|
||
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TARGET ORGANISM->INHIBITOR |
Chimeric replicons containing different
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SALT/SOLVATE -> PARENT |
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TARGET ORGANISM->INHIBITOR |
Chimeric replicons containing different
NS5B genotype gt 1a.
EC50
|
||
|
TARGET -> INHIBITOR |
IC50
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|
BINDER->LIGAND |
BINDING
|
||
|
TARGET ORGANISM->INHIBITOR |
Chimeric replicons containing different
NS5B genotype 3a.
EC50
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
|
