U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Wed Apr 02 20:10:51 GMT 2025
Edited
by admin
on Wed Apr 02 20:10:51 GMT 2025
Source Materials Class ORGANISM
Source Materials Type RECOMBINANT VIRUS
Source Materials State LIVE CONDITIONALLY-REPLICATING GENETICALLY MODIFIED
Organism Family Adenoviridae
Organism Genus Mastadenovirus
Organism Species human mastadenovirus d
Author NONE
Infraspecific Type RECOMBINANT VECTOR
Infraspecific Name Ad5-hyaluronidase PH-20
Part whole
Record UNII
3HBM7CA87P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Zabilugene Almadenorepvec
INN  
Official Name English
DNA (recombinant tumor-selective replicating oncolytic human adenovirus 5 vector VCN-01 transcription factor E2F-binding boxes plus transcription factor SP1-binding box-containing promoter 415 plus human adenovirus 5 gene E1A-?24 plus human hyaluronidase
Preferred Name English
KKTK domain of the fiber shaft with an integrin-binding, tumour-selectirecombinant, replication-competent oncolytic human adenovirus type 5 (Ad5) vector, encoding human hyaluronidase PH-20 (sperm adhesion molecule 1 [SPAM1] soluble form), under the contr
Common Name English
zabilugene almadenorepvec [INN]
Common Name English
Code System Code Type Description
SMS_ID
100000182774
Created by admin on Wed Apr 02 20:10:51 GMT 2025 , Edited by admin on Wed Apr 02 20:10:51 GMT 2025
PRIMARY
INN
13271
Created by admin on Wed Apr 02 20:10:51 GMT 2025 , Edited by admin on Wed Apr 02 20:10:51 GMT 2025
PRIMARY
NCI_THESAURUS
C211709
Created by admin on Wed Apr 02 20:10:51 GMT 2025 , Edited by admin on Wed Apr 02 20:10:51 GMT 2025
PRIMARY
CAS
2937327-18-7
Created by admin on Wed Apr 02 20:10:51 GMT 2025 , Edited by admin on Wed Apr 02 20:10:51 GMT 2025
PRIMARY
FDA UNII
3HBM7CA87P
Created by admin on Wed Apr 02 20:10:51 GMT 2025 , Edited by admin on Wed Apr 02 20:10:51 GMT 2025
PRIMARY
Related Record Type Details
EXPRESSED PROTEIN->VECTOR
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
Whole genome including all the modifications Zabilugene almadenorepvec whole genome 6QG3Q7EVL6