Anbenitamab Repodatecan

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 21:20:51 GMT 2025` Edited by `admin` on `Wed Apr 02 21:20:51 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY CONJUGATE
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	3U4SXA9ADW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Immunoglobulin G1 [369-serine,371-alanine,408-lysine,410-valine], anti-(human epidermal growth factor receptor HER2 domain IV) (human-Mus musculus monoclonal rhuMab 4D5 ?1-chain), disulfide with human-Mus musculus monoclonal rhuMab 4D5 ?-chain, (229?228?

Preferred Name

English

Anbenitamab Repodatecan

Official Name

English

anbenitamab repodatecan [INN]

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody, bispecific biparatopic, tetravalent, conjugated

Common Name

English

Code System Code Type Description

CAS

2923420-38-4

Created by admin on Wed Apr 02 21:20:51 GMT 2025 , Edited by admin on Wed Apr 02 21:20:51 GMT 2025

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FDA UNII

3U4SXA9ADW

Created by admin on Wed Apr 02 21:20:51 GMT 2025 , Edited by admin on Wed Apr 02 21:20:51 GMT 2025

PRIMARY

INN

13457

Created by admin on Wed Apr 02 21:20:51 GMT 2025 , Edited by admin on Wed Apr 02 21:20:51 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_146	2_202
2_263	2_323
1_147	1_203
3_23	3_88
4_23	4_88
1_229	2_228
1_232	2_231
1_264	1_324
1_370	1_428
2_222	4_214
1_223	3_214
2_369	2_427
3_134	3_194
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_299

Related Record Type Details


					OC71PP0F89

EXATECAN

TOXIN -> CONJUGATE

Amount:


					7J9Y28299R

RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2

TARGET->LIGAND

Amount:


					RHS90QRF9E

ANBENITAMAB

PARENT -> CONJUGATE

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
	CONJUGATION	CHEMICAL		DBCO-PEG4-GGFG-Exatecan	7L3XY83XWU

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_300] [2_299]			Amount:	Anbenitamab repodatecan asparagine modification	AZ4UZN9LF2
AMINO ACID REMOVAL	[1_450] [2_449]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL