N6-ACETYLLYSINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C8H16N2O3
Molecular Weight	188.2242
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)NCCCC[C@H](N)C(O)=O

InChI

InChIKey=DTERQYGMUDWYAZ-ZETCQYMHSA-N

InChI=1S/C8H16N2O3/c1-6(11)10-5-3-2-4-7(9)8(12)13/h7H,2-5,9H2,1H3,(H,10,11)(H,12,13)/t7-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C8H16N2O3
Molecular Weight	188.2242
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Nε-lysine acetylation of a bacterial transcription factor inhibits Its DNA-binding activity.	2010-12-31	21217812
Transition state of ADP-ribosylation of acetyllysine catalyzed by Archaeoglobus fulgidus Sir2 determined by kinetic isotope effects and computational approaches.	2010-09-08	20718419
N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2.	2010-08-01	20630764
Synthetic biology approaches in drug discovery and pharmaceutical biotechnology.	2010-06	20396881
Degradation of 1-deoxy-D-erythro-hexo-2,3-diulose in the presence of lysine leads to formation of carboxylic acid amides.	2010-05-26	20429584
A convenient method for genetic incorporation of multiple noncanonical amino acids into one protein in Escherichia coli.	2010-04	20237646
Substrate specificity of SIRT1-catalyzed lysine Nepsilon-deacetylation reaction probed with the side chain modified Nepsilon-acetyl-lysine analogs.	2010-02	19914676
A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation.	2009-10-09	19818718
Plasmodium falciparum Sir2 is an NAD+-dependent deacetylase and an acetyllysine-dependent and acetyllysine-independent NAD+ glycohydrolase.	2008-09-23	18729382
Adding l-lysine derivatives to the genetic code of mammalian cells with engineered pyrrolysyl-tRNA synthetases.	2008-07-11	18471995
Utility of immonium ions for assignment of epsilon-N-acetyllysine-containing peptides by tandem mass spectrometry.	2008-05-01	18338905
Genetically encoding N(epsilon)-acetyllysine in recombinant proteins.	2008-04	18278036
A spectrophotometric assay for histone deacetylase 8.	2008-01-01	17920554
Substituting N(epsilon)-thioacetyl-lysine for N(epsilon)-acetyl-lysine in peptide substrates as a general approach to inhibiting human NAD(+)-dependent protein deacetylases.	2008-01	19325715
Characterization of Nalpha-benzyloxycarbonyl-L-lysine oxidizing enzyme from Rhodococcus sp. AIU Z-35-1.	2007-09	17964487
N(epsilon)-methanesulfonyl-lysine as a non-hydrolyzable functional surrogate for N(epsilon)-acetyl-lysine.	2007-03-21	17340003
Nepsilon-thioacetyl-lysine: a multi-facet functional probe for enzymatic protein lysine Nepsilon-deacetylation.	2006-07-15	16697640
Proteomic analysis of organ-specific post-translational lysine-acetylation and -methylation in mice by use of anti-acetyllysine and -methyllysine mouse monoclonal antibodies.	2005-12	16247734
Purification and characterization of a novel aminoacylase from Streptomyces mobaraensis.	2005-10	16244442
Kinetics and comparative reactivity of human class I and class IIb histone deacetylases.	2004-08-31	15323567
Four different clones of mouse anti-acetyllysine monoclonal antibodies having different recognition properties share a common immunoglobulin framework structure.	2003-01-15	12505721
Switching osmolyte strategies: response of Methanococcus thermolithotrophicus to changes in external NaCl.	2001-11-15	11078952
A case of hyperlysinemia: biochemical and clinical observations.	1967-04	6022933

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:20:49 GMT 2025` Edited by `admin` on `Mon Mar 31 22:20:49 GMT 2025`
Record UNII	470AD5VY1X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N6-ACETYLLYSINE

Systematic Name

English

NSC-102777

Preferred Name

English

N.EPSILON.-ACETYL-L-LYSINE

Systematic Name

English

N6-ACETYL-L-LYSINE

Systematic Name

English

.EPSILON.-N-ACETYLLYSINE

Common Name

English

LYSINE, N6-ACETYL-

Systematic Name

English

Classification Tree Code System Code

LOINC

79578-1