Disitamab

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 02:23:00 GMT 2025` Edited by `admin` on `Wed Apr 02 02:23:00 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	474FJM6Y9C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

disitamab [INN]

Preferred Name

English

Disitamab

Official Name

English

RC-48

Code

English

RC48

Code

English

Immunoglobulin G1, anti-(human tyrosine kinase receptor ErbB2) (human-Mus musculus monoclonal RC48-0 ?1-chain), disulfide with human-Mus musculus monoclonal RC48-0 ?-chain, dimer

Common Name

English

DISITAMAB [USAN]

Common Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody; gamma1 heavy chain humanized (1-445) [VH (Homo s

Common Name

English

Code System Code Type Description

CAS

2185868-98-6

Created by admin on Wed Apr 02 02:23:00 GMT 2025 , Edited by admin on Wed Apr 02 02:23:00 GMT 2025

PRIMARY

SMS_ID

300000005935

Created by admin on Wed Apr 02 02:23:00 GMT 2025 , Edited by admin on Wed Apr 02 02:23:00 GMT 2025

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USAN

MN-185

Created by admin on Wed Apr 02 02:23:00 GMT 2025 , Edited by admin on Wed Apr 02 02:23:00 GMT 2025

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INN

11048

Created by admin on Wed Apr 02 02:23:00 GMT 2025 , Edited by admin on Wed Apr 02 02:23:00 GMT 2025

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NCI_THESAURUS

C166732

Created by admin on Wed Apr 02 02:23:00 GMT 2025 , Edited by admin on Wed Apr 02 02:23:00 GMT 2025

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FDA UNII

474FJM6Y9C

Created by admin on Wed Apr 02 02:23:00 GMT 2025 , Edited by admin on Wed Apr 02 02:23:00 GMT 2025

PRIMARY

From	To
1_22	1_96
1_142	1_198
1_218	3_212
1_224	2_224
1_227	2_227
1_259	1_319
1_365	1_423
2_22	2_96
2_142	2_198
2_218	4_212
2_259	2_319
2_365	2_423
3_23	3_88
3_132	3_192
4_23	4_88
4_132	4_192

Glycosylation Link Type	Site
N	1_295
N	2_295

Related Record Type Details


					7J9Y28299R

RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2

TARGET -> INHIBITOR

Amount:


					RB3U3A1S27

Disitamab Vedotin

CONJUGATE -> PARENT

Amount:

Related Record Type Details


					474FJM6Y9C

Disitamab

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL