BIFLURANOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H18F2O2
Molecular Weight	292.3204
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC[C@H]([C@H](C)C1=CC(F)=C(O)C=C1)C2=CC=C(O)C(F)=C2

InChI

InChIKey=RDVXUHOSYIBGBT-ZWNOBZJWSA-N

InChI=1S/C17H18F2O2/c1-3-13(12-5-7-17(21)15(19)9-12)10(2)11-4-6-16(20)14(18)8-11/h4-10,13,20-21H,3H2,1-2H3/t10-,13-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C17H18F2O2
Molecular Weight	292.3204
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://doi.org/10.1002/pros.2990070403 | https://www.ncbi.nlm.nih.gov/pubmed/2559252

Bifluranol (brand name Prostarex), a fluorinated bibenzyl anti-androgen was developed as a nonsteroidal estrogen and was studied for the treatment of benign prostatic hyperplasia. Besides, was shown that bifluranol inhibited 17 alpha-hydroxylase/C17-C20 lyase.

Approval Year

PubMed

Title	Date	PubMed
Bifluranol, a novel fluorinated bibenzyl anti-androgen, its chemistry and disposition in different animal species.	1981-05	6116777
Anti-prostatic activity of bifluranol, a fluorinated bibenzyl.	1980	6258683
Comparison of the novel bibenzyl bifluranol with diethystilboestrol: effect of aromatic fluorine substitution on metabolism [proceedings].	1978-06	667433

Sample Use Guides

In Vivo Use Guide

Thirty five patients with bladder outflow obstruction received either Bifluranol 1.5 mg orally, t.d.s. or placebo in a double‐blind trial.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:02:03 GMT 2025` Edited by `admin` on `Mon Mar 31 18:02:03 GMT 2025`
Record UNII	47602X79JF
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BX 341

Preferred Name

English

BIFLURANOL

Official Name

English

BX-341

Code

English

BIFLURANOL [MI]

Common Name

English

BIFLUORANOL

Common Name

English

bifluranol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C242