U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C14H9Cl3N2OS
Molecular Weight 359.658
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRICLABENDAZOLE

SMILES

CSC1=NC2=C(N1)C=C(OC3=CC=CC(Cl)=C3Cl)C(Cl)=C2

InChI

InChIKey=NQPDXQQQCQDHHW-UHFFFAOYSA-N
InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)

HIDE SMILES / InChI
Molecular Formula C14H9Cl3N2OS
Molecular Weight 359.658
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/triclabendazole.html | https://www.drugs.com/mmx/triclabendazole.html | https://www.ncbi.nlm.nih.gov/pubmed/15259481 | https://www.ncbi.nlm.nih.gov/pubmed/26312936

Triclabendazole, (brand name Avomec, Egaten, etc) is a member of the benzimidazole family of anthelmintics used to treat liver flukes, specifically fascioliasis and paragonimiasis. Triclabendazole used routinely since 1983 in veterinary practice for the treatment of fascioliasis. It was not used in humans until the 1989 epidemic of fascioliasis near the Caspian Sea when Iranian authorities approved the use of the veterinary formulation to treat the infection. Fasciolicidal not only against the adult worms present in the biliary ducts, but also against the immature larval stages of Fasciola migrating through the hepatic parenchyma. Triclabendazole is shown to penetrate into liver flukes by transtegumentary absorption followed by inhibition of the parasite's motility, probably related to the destruction of the microtubular structure, resulting in the death of the parasite; the immobilizing effect is paralleled by changes in the parasite's resting tegumental membrane potential, strongly inhibiting the release of proteolytic enzymes, a process that appears critical to the survival of the parasite. Side effects are generally few, but can include abdominal pain and headaches. Biliary colic may occur due to dying worms. While no harms have been found with use during pregnancy, triclabendazole has not been well studied in this population. Triclabendazole is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is not commercially available in the United States.

Originator

Approval Year

2019
334
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8504
 15.0 µM [IC50]
Inhibitor
8504
Inhibitor
8504
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8583
Egaten

Approved Use

Unknown
Curative
Approved
8583
Egaten

Approved Use

Unknown
Curative
Approved
8583
Egaten

Approved Use

Unknown
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
0.34 μM
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/9663817/
10 mg/kg 1 times / day multiple, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TRICLABENDAZOLE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
1.16 μM
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/9663817/
10 mg/kg 1 times / day multiple, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TRICLABENDAZOLE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
1.16 μM
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
10 mg/kg single, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
TRICLABENDAZOLE plasma
Homo sapiens
population: UNHEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1.55 μM × h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/9663817/
10 mg/kg 1 times / day multiple, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TRICLABENDAZOLE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
5.72 μM × h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/9663817/
10 mg/kg 1 times / day multiple, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TRICLABENDAZOLE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
5.72 μM × h
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
10 mg/kg single, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
TRICLABENDAZOLE plasma
Homo sapiens
population: UNHEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
8 h
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
10 mg/kg single, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
TRICLABENDAZOLE plasma
Homo sapiens
population: UNHEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
3.3%
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
10 mg/kg single, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
TRICLABENDAZOLE plasma
Homo sapiens
population: UNHEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 12-60 years
Health Status: unhealthy
Age Group: 12-60 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Other AEs: Abdominal pain, Headache...
Other AEs:
Abdominal pain (6.4%)
Headache (10.6%)
Dizziness (4.3%)
Jaundice (2.1%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 4-68 years
Health Status: unhealthy
Age Group: 4-68 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Other AEs: Dizziness, Abdominal pain...
Other AEs:
Dizziness (5.4%)
Abdominal pain (1.3%)
Diarrhea (1.3%)
Fever (1.9%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 5-54 years
Health Status: unhealthy
Age Group: 5-54 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Other AEs: Headache, Abdominal pain...
Other AEs:
Headache (5.7%)
Abdominal pain (5.7%)
Vomiting (2.9%)
Diarrhea (2.9%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
10 mg/kg 1 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
Other AEs: Abdominal pain, Biliary colic...
Other AEs:
Abdominal pain (grade 3, 1.2%)
Biliary colic (grade 1-2, 49%)
Jaundice (grade 1-2, 7.2%)
Epigastric pain (grade 1-2, 42.7%)
Nausea (grade 1-2, 8.5%)
Fever (grade 1-2, 8.5%)
Pruritus (grade 1-2, 6.1%)
Urticaria (grade 1-2, 2.4%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
10 mg/kg 2 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 2 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Other AEs: Abdominal pain, Hyperhidrosis...
Other AEs:
Abdominal pain (93%)
Hyperhidrosis (25%)
Nausea (18%)
Urticaria (11%)
Vomiting (7%)
Headache (14%)
Pruritus (4%)
Musculoskeletal chest pain (4%)
Decreased appetite (18%)
Diarrhea (7%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
15 mg/kg single, oral
Recommended
Dose: 15 mg/kg
Route: oral
Route: single
Dose: 15 mg/kg
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Other AEs: Bilirubin increased, AST increased...
Other AEs:
Bilirubin increased (6.8%)
AST increased (4.5%)
Alkaline phosphatase increased (4.2%)
ALT increased (3%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Other AEs: Abdominal pain, Hyperhidrosis...
Other AEs:
Abdominal pain (56%)
Hyperhidrosis (23%)
Vertigo (9%)
Nausea (8%)
Urticaria (7%)
Vomiting (6%)
Headache (6%)
Dyspnea (5%)
Pruritus (4%)
Asthenia (4%)
Musculoskeletal chest pain (4%)
Cough (4%)
Decreased appetite (3%)
Chest pain (3%)
Pyrexia (2%)
Jaundice (2%)
Chest discomfort (2%)
Constipation (< 2%)
Biliary colic (< 2%)
Arthralgia (< 2%)
Back pain (< 2%)
Spinal pain (< 2%)
Chromaturia (< 2%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
10 mg/kg 1 times / day multiple, oral
Highest studied dose
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age 16.3 years
Health Status: unhealthy
Age Group: mean age 16.3 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Other AEs: Abdominal pain, Fatigue...
Other AEs:
Abdominal pain (grade 1, 100%)
Fatigue (grade 1, 50%)
Headache (grade 1-2, 75%)
Diarrhea (grade 1, 25%)
Nausea (grade 1, 75%)
Vomiting (grade 1, 25%)
Fever (grade 1-2, 25%)
Dizziness (grade 1, 50%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age14.4 years
Health Status: unhealthy
Age Group: mean age14.4 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Other AEs: Abdominal pain, Fatigue...
Other AEs:
Abdominal pain (grade 1-2)
Fatigue (grade 1)
Headache (grade 1-2)
Diarrhea (grade 1-2)
Vomiting (grade 1)
Fever (grade 1-2)
Dizziness (grade 1)
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
AEs

AEs

AESignificanceDosePopulation
Headache 10.6%
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 12-60 years
Health Status: unhealthy
Age Group: 12-60 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Jaundice 2.1%
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 12-60 years
Health Status: unhealthy
Age Group: 12-60 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Dizziness 4.3%
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 12-60 years
Health Status: unhealthy
Age Group: 12-60 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Abdominal pain 6.4%
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 12-60 years
Health Status: unhealthy
Age Group: 12-60 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Abdominal pain 1.3%
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 4-68 years
Health Status: unhealthy
Age Group: 4-68 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Diarrhea 1.3%
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 4-68 years
Health Status: unhealthy
Age Group: 4-68 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Fever 1.9%
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 4-68 years
Health Status: unhealthy
Age Group: 4-68 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Dizziness 5.4%
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 4-68 years
Health Status: unhealthy
Age Group: 4-68 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Diarrhea 2.9%
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 5-54 years
Health Status: unhealthy
Age Group: 5-54 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Vomiting 2.9%
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 5-54 years
Health Status: unhealthy
Age Group: 5-54 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Abdominal pain 5.7%
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 5-54 years
Health Status: unhealthy
Age Group: 5-54 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Headache 5.7%
10 mg/kg 1 times / 8 hours multiple, oral
Dose: 10 mg/kg, 1 times / 8 hours
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / 8 hours
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
unhealthy, 5-54 years
Health Status: unhealthy
Age Group: 5-54 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208711Orig1s000MultidisciplineR.pdf
Urticaria grade 1-2, 2.4%
10 mg/kg 1 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
Epigastric pain grade 1-2, 42.7%
10 mg/kg 1 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
Biliary colic grade 1-2, 49%
10 mg/kg 1 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
Pruritus grade 1-2, 6.1%
10 mg/kg 1 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
Jaundice grade 1-2, 7.2%
10 mg/kg 1 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
Fever grade 1-2, 8.5%
10 mg/kg 1 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
Nausea grade 1-2, 8.5%
10 mg/kg 1 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
Abdominal pain grade 3, 1.2%
10 mg/kg 1 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/11421375/
Urticaria 11%
10 mg/kg 2 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 2 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Headache 14%
10 mg/kg 2 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 2 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Decreased appetite 18%
10 mg/kg 2 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 2 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Nausea 18%
10 mg/kg 2 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 2 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Hyperhidrosis 25%
10 mg/kg 2 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 2 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Musculoskeletal chest pain 4%
10 mg/kg 2 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 2 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Pruritus 4%
10 mg/kg 2 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 2 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Diarrhea 7%
10 mg/kg 2 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 2 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Vomiting 7%
10 mg/kg 2 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 2 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Abdominal pain 93%
10 mg/kg 2 times / day multiple, oral
Recommended
Dose: 10 mg/kg, 2 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
ALT increased 3%
15 mg/kg single, oral
Recommended
Dose: 15 mg/kg
Route: oral
Route: single
Dose: 15 mg/kg
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Alkaline phosphatase increased 4.2%
15 mg/kg single, oral
Recommended
Dose: 15 mg/kg
Route: oral
Route: single
Dose: 15 mg/kg
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
AST increased 4.5%
15 mg/kg single, oral
Recommended
Dose: 15 mg/kg
Route: oral
Route: single
Dose: 15 mg/kg
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Bilirubin increased 6.8%
15 mg/kg single, oral
Recommended
Dose: 15 mg/kg
Route: oral
Route: single
Dose: 15 mg/kg
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Chest discomfort 2%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Jaundice 2%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Pyrexia 2%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Hyperhidrosis 23%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Chest pain 3%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Decreased appetite 3%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Asthenia 4%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Cough 4%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Musculoskeletal chest pain 4%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Pruritus 4%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Dyspnea 5%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Abdominal pain 56%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Headache 6%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Vomiting 6%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Urticaria 7%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Nausea 8%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Vertigo 9%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Arthralgia < 2%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Back pain < 2%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Biliary colic < 2%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Chromaturia < 2%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Constipation < 2%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Spinal pain < 2%
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
unhealthy, adult | children
Health Status: unhealthy
Age Group: adult | children
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf
Abdominal pain grade 1, 100%
10 mg/kg 1 times / day multiple, oral
Highest studied dose
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age 16.3 years
Health Status: unhealthy
Age Group: mean age 16.3 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Diarrhea grade 1, 25%
10 mg/kg 1 times / day multiple, oral
Highest studied dose
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age 16.3 years
Health Status: unhealthy
Age Group: mean age 16.3 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Vomiting grade 1, 25%
10 mg/kg 1 times / day multiple, oral
Highest studied dose
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age 16.3 years
Health Status: unhealthy
Age Group: mean age 16.3 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Dizziness grade 1, 50%
10 mg/kg 1 times / day multiple, oral
Highest studied dose
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age 16.3 years
Health Status: unhealthy
Age Group: mean age 16.3 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Fatigue grade 1, 50%
10 mg/kg 1 times / day multiple, oral
Highest studied dose
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age 16.3 years
Health Status: unhealthy
Age Group: mean age 16.3 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Nausea grade 1, 75%
10 mg/kg 1 times / day multiple, oral
Highest studied dose
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age 16.3 years
Health Status: unhealthy
Age Group: mean age 16.3 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Fever grade 1-2, 25%
10 mg/kg 1 times / day multiple, oral
Highest studied dose
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age 16.3 years
Health Status: unhealthy
Age Group: mean age 16.3 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Headache grade 1-2, 75%
10 mg/kg 1 times / day multiple, oral
Highest studied dose
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age 16.3 years
Health Status: unhealthy
Age Group: mean age 16.3 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Dizziness grade 1
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age14.4 years
Health Status: unhealthy
Age Group: mean age14.4 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Fatigue grade 1
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age14.4 years
Health Status: unhealthy
Age Group: mean age14.4 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Vomiting grade 1
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age14.4 years
Health Status: unhealthy
Age Group: mean age14.4 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Abdominal pain grade 1-2
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age14.4 years
Health Status: unhealthy
Age Group: mean age14.4 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Diarrhea grade 1-2
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age14.4 years
Health Status: unhealthy
Age Group: mean age14.4 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Fever grade 1-2
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age14.4 years
Health Status: unhealthy
Age Group: mean age14.4 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Headache grade 1-2
10 mg/kg 1 times / day single, oral
Dose: 10 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 10 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
unhealthy, mean age14.4 years
Health Status: unhealthy
Age Group: mean age14.4 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/21909440/
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
inhibitor
2438

substrate
1193
inhibitor
2507

substrate
1388

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP1A2
2153

CYP2B6
926

CYP2C8
1057

CYP2C19
2057

CYP3A
227

CYP2E1
1060

BCRP
910
CYP1A2
1197

CYP2C19
1119

CYP3A
220

FMO
34

CYP1A1
389

CYP1B1
104

CYP2C18
149

UGT1A4
399

UGT1A8
323

UGT1A9
423

P-gp
2052
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
CYP2E1
1146
 no
CYP2E1
1146
 no
TCBZ-SO
1
CYP2E1
1146
 no
TCBZ-SO2
1
CYP2D6
2546
 yes [Ki 0.009 uM]
CYP2B6
1160
 yes [Ki 0.016 uM]
CYP2C8
1117
 yes [Ki 0.018 uM]
CYP2D6
2546
 yes [Ki 0.05 uM]
TCBZ-SO
1
CYP2C9
2497
 yes [Ki 0.053 uM]
CYP2C19
2141
 yes [Ki 0.061 uM]
CYP1A2
2333
 yes [Ki 0.149 uM]
TCBZ-SO
1
CYP3A
317
 yes [Ki 0.166 uM]
CYP2C9
2497
 yes [Ki 0.22 uM]
TCBZ-SO2
1
CYP2C8
1117
 yes [Ki 0.37 uM]
TCBZ-SO2
1
CYP2C19
2141
 yes [Ki 0.57 uM]
TCBZ-SO
1
CYP2B6
1160
 yes [Ki 0.75 uM]
TCBZ-SO
1
CYP2C8
1117
 yes [Ki 1.03 uM]
TCBZ-SO
1
CYP2B6
1160
 yes [Ki 1.27 uM]
TCBZ-SO2
1
CYP2C9
2497
 yes [Ki 1.81 uM]
TCBZ-SO
1
CYP1A2
2333
 yes [Ki 12.5 uM]
TCBZ-SO2
1
CYP2D6
2546
 yes [Ki 13 uM]
TCBZ-SO2
1
CYP3A
317
 yes [Ki 2.31 uM]
TCBZ-SO2
1
CYP2C19
2141
 yes [Ki 2.77 uM]
TCBZ-SO2
1
CYP3A
317
 yes [Ki 4.32 uM]
TCBZ-SO
1
BCRP
985
 yes
BCRP
985
 yes
TCBZ-SO
1
BCRP
985
 yes
TCBZ-SO2
1
CYP1A2
2333
 yes
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
CYP1A1
389
 yes
CYP1A1
389
 yes
TCBZ-SO
1
CYP1A2
1197
 yes
CYP1A2
1197
 yes
TCBZ-SO
1
CYP1B1
104
 yes
CYP1B1
104
 yes
TCBZ-SO
1
CYP2C18
149
 yes
CYP2C19
1119
 yes
CYP2C19
1119
 yes
TCBZ-SO
1
CYP2C9
1193
 yes
CYP2D6
1388
 yes
CYP3A
220
 yes
FMO
34
 yes
FMO
34
 yes
TCBZ-SO
1
P-gp
2052
 yes
UGT1A4
399
 yes
UGT1A8
323
 yes
UGT1A9
423
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
NO19265
https://www.001chemical.com/chem/68786-66-3
3B Scientific (Wuhan) Corp
3B2-0397
http://www.3bsc.com/index/pro_info.php?id=19753
AA Blocks
AA006H2T
http://www.aablocks.com/goods/Goods/detail?id=AA006H2T
Aaron Chemicals
AR006HUL
http://www.aaronchem.com/68786-66-3
abcr GmbH
AB425871
http://www.abcr.com/shop/en/AB425871
AbMole Bioscience
M3086
http://www.abmole.com/products/triclabendazole.html
Achemo Scientific Limited
AC-14758
http://www.achemo.com/search/?Keyword= 68786-66-3
Achemtek
0104-023305
http://www.achemtek.com/68786-66-3
Acros Organics
AC461960010
https://www.fishersci.com/shop/products/triclabendazole-98-acros-organics-1/AC461960010
Acros Organics
AC461960050
https://www.fishersci.com/shop/products/triclabendazole-98-acros-organics/AC461960050
AEchem Scientific Corp., USA
AE1-012796
http://www.aechemsc.com/info_products/AE1-012796.php
AHH Chemical co.,ltd
API-1377
http://www.ahhchemical.com/product/API-1377.html
AK Scientific, Inc. (AKSCI)
I018
http://www.aksci.com/item_detail.php?cat=I018
Alfa Chemistry
68786-66-3
https://www.alfa-chemistry.com/triclabendazole-cas-68786-66-3-item-293302.htm
Alfa Chemistry
AP68786663
https://reagents.alfa-chemistry.com/product/triclabendazole-cas-68786-66-3-15149.html
Ambinter
Amb1064227
http://www.ambinter.com/reference/1064227
Angene
AGN-PC-0WAFFY
http://www.angenechemical.com/productshow/AGN-PC-0WAFFY.html
Anward
ANW-42745
http://www.anward.com/pro_result/29972
ApexBio Technology
B1860
http://www.apexbt.com/triclabendazole-28619.html
Ark Pharm
AK-68238
http://www.arkpharminc.com/products/68786-66-3.html
Aurum Pharmatech LLC
MP-0274
http://www.Aurumpharmatech.com/Product/ProductDetails/MP_0274
BioCrick
BCC4742
http://www.biocrick.com/Triclabendazole-BCC4742.html
BLD Pharm
BD34628
http://www.bldpharm.com/products/68786-66-3.html
Chem Scene
CS-2859
http://www.chemscene.com/68786-66-3.html
ChemMol
30101568
http://www.chemmol.com/chemmol/30101568.html
ChemMol
49403233
http://www.chemmol.com/chemmol/49403233.html
ChemMol
99130410
http://www.chemmol.com/chemmol/99130410.html
ChemShuttle
151876
http://www.chemshuttle.com/catalogsearch/result/?q=68786-66-3&cat=
Chemspace
CSSB00016988883
https://chem-space.com/CSSB00016988883
Clearsynth
CS-W-00074
https://www.clearsynth.com/en/CSW00074.html
CSNpharm
CSN16451
https://www.csnpharm.com/products/triclabendazole.html
DC Chemicals
DC32992
http://www.dcchemicals.com//product_show-Triclabendazole.html
eNovation Chemicals
D520206
https://www.enovationchem.com/ProductDetails.asp?ProductID=D520206
Finetech
FT-0602564
http://www.finetechnology-ind.com/prod/detail/pub/68786-66-3.html
Glentham Life Sciences
GP3360
http://www.glentham.com/products/product/GP3360/
Hairui
HR115473
http://www.hairuichem.com/en/product/68786-66-3.html
Huateng Pharma
F80017899
http://en.huatengsci.com/product/Triclabendazole.html
iChemical
EBD22541
http://www.ichemical.com/products/68786-66-3.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
Lab Network
LN00176318
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00176318
LGC Standards
DRE-A17795000AL-100
https://www.lgcstandards.com/US/en/p/DRE-A17795000AL-100
LGC Standards
DRE-C17795000
https://www.lgcstandards.com/US/en/p/DRE-C17795000
LGC Standards
LGCFOR0313.00
https://www.lgcstandards.com/US/en/p/LGCFOR0313.00
LGC Standards
MM0313.00
https://www.lgcstandards.com/US/en/p/MM0313.00
Matrix Scientific
76003
https://www.matrixscientific.com/076003.html
mcule
MCULE-8131756770
https://mcule.com/MCULE-8131756770/
MedChem Express
HY-B0621
https://www.medchemexpress.com/triclabendazole.html
Molcore
CS19265
https://www.molcore.com/product/68786-66-3
MuseChem
A000387
https://www.musechem.com/product/A000387.html
Oakwood
79305
http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=64479&ExtHyperLink=1
OChem
5477
http://www.ocheminc.com/index.php?act=psearch&pid=786T663
Parchem
34541
http://www.parchem.com/chemical-supplier-distributor/Triclabendazole-024541.aspx
Sigma-Aldrich
32802_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/32802?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
Y0001723_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/y0001723?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
Y0001737_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/y0001737?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule
S545823
http://www.smolecule.com/products/s545823
Synblock Inc
SB17173
http://www.synblock.com/product/68786-66-3.html
TCI (Tokyo Chemical Industry)
T2826
http://www.tcichemicals.com/eshop/en/us/commodity/T2826/index.html
THE BioTek
bt-286752
https://www.thebiotek.com/product/inhibitors/bt-286752
VladaChem
VL282319-10G
https://www.vladachem.com/product.php?products=68786-66-3
Yuhao Chemical
RT19019
http://www.chemyuhao.com/68786-66-3.html
PubMed

PubMed

TitleDatePubMed
A field trial of production and financial consequences of helminthosis control in sheep production in Ethiopia.
2008-04-17
Use of triclabendazole for treatment of patients co-infected by Fasciola spp. and S. mansoni in Behera Governorate, Egypt.
2008-03
Natural history, clinicoradiologic correlates, and response to triclabendazole in acute massive fascioliasis.
2008-02
Pharmacokinetic disposition of triclabendazole in cattle and sheep; discrimination of the order and the rate of the absorption process of its active metabolite triclabendazole sulfoxide.
2008-01
Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica.
2007-12
Food-borne trematodiasis: current chemotherapy and advances with artemisinins and synthetic trioxolanes.
2007-11
Obstructive jaundice with fever and eosinophilia.
2007-11
[Fascioliasis: a 23-year retrospective study].
2007-11
[Obstructive jaundice, Fasciola hepatica: a new case report].
2007-10-31
Fasciola hepatica: the infectivity of cattle-origin miracidia had increased over the past years in central France.
2007-09
Controlling fasciolosis in the Bolivian Altiplano.
2007-06
Effect of Fascioliasis on the pharmacokinetic parameters of triclabendazole in human subjects.
2007-06
The effect of diet type on the plasma disposition of triclabendazole in goats.
2007-06
Surgery in Fasciola hepatica pancreatitis: report of a case and review of literature.
2007-04
Understanding triclabendazole resistance.
2007-04
Fasciola hepatica: ultrastructural effects of a combination of triclabendazole and clorsulon against mature fluke.
2007-04
An in vitro effect of propolis on adult worms of Fasciola gigantica.
2007-03-31
The use of MM3 monoclonal antibodies for the early immunodiagnosis of ovine fascioliasis.
2007-02
A case of human fasciolosis: discrepancy between egg size and genotype of Fasciola sp.
2007-02
[New drugs against parasitic diseases].
2007-01-31
Immature triclabendazole-resistant Fasciola hepatica: tegumental responses to in vitro treatment with the sulphoxide metabolite of the experimental fasciolicide compound alpha.
2007-01
Human fascioliasis: a case of hyperinfection and an update for clinicians.
2007
Resistance-induced changes in triclabendazole transport in Fasciola hepatica: ivermectin reversal effect.
2006-12
[Hepatobiliary fasciolasis without eosinophilia].
2006-10
Fasciola hepatica: morphological effects of a combination of triclabendazole and clorsulon against mature fluke.
2006-10
Resistance of Fasciola hepatica to triclabendazole and albendazole in sheep in Spain.
2006-09-23
[Therapeutic alternatives in case of failure of first-line treatment of intestinal helminthiasis in adults].
2006-08
Triclabendazole and its two main metabolites lack activity against Schistosoma mansoni in the mouse model.
2006-08
Adult triclabendazole-resistant Fasciola hepatica: surface and subsurface tegumental responses to in vitro treatment with the sulphoxide metabolite of the experimental fasciolicide compound alpha.
2006-08
Stage-specific differences in fecundity over the life-cycle of two characterized isolates of the liver fluke, Fasciola hepatica.
2006-08
Response from Savioli and colleagues from the Department of Neglected Tropical Diseases, World Health Organization.
2006-06
Assessment of the main metabolism pathways for the flukicidal compound triclabendazole in sheep.
2006-06
Systemic vasculitis associated with Fasciola hepatica infection.
2006-04-28
Fasciola hepatica infection: clinical and computerized tomographic findings of ten patients.
2006-03
Field trial on comparative efficacy of four fasciolicides against natural liver fluke infection in cattle.
2006-02-18
[Design of a Russian sample of the antifascioliasis antihelminthic triclabendazole and evaluation of its therapeutic efficiency].
2006-02-01
Treatment of fascioliasis in human infections.
2006-02
Seasonal differences in the incidence of infection with Fasciola gigantica in Cambodian cattle.
2006-01
Eight cases of fascioliasis: clinical and microbiological features.
2006-01
Triclabendazole for the treatment of fascioliasis and paragonimiasis.
2005-12
Infection with Fasciola hepatica.
2005-11
An outbreak of subacute fasciolosis in Soay sheep: ultrasonographic biochemical and histological studies.
2005-11
Eurytrema pancreaticum: the in vitro effect of praziquantel and triclabendazole on the adult fluke.
2005-11
Emerging foodborne trematodiasis.
2005-10
Altered drug influx/efflux and enhanced metabolic activity in triclabendazole-resistant liver flukes.
2005-10
Fascioliasis in relatives of patients with Fasciola hepatica infection in Peru.
2005-09-03
Triclabendazole: new skills to unravel an old(ish) enigma.
2005-09
Monitoring and treatment of Fascioloides magna in semi-farm red deer husbandry in Croatia.
2005-08
Fascioliasis imported to Norway.
2005
Experimental infection of rabbits with Fasciola gigantica and treatment with triclabendazole (TCBZ) or BT6: parasitological, haematological and immunological findings.
2001
Patents

Patents

BE865870
1
DE2815621
1
NL7803886
1

Sample Use Guides

In Vivo Use Guide
10 mg per kg of body weight as a single dose
Route of Administration: Oral
In Vitro Use Guide
Triclabendazole was tested in vitro against recently excysted metacercariae. Triclabendazole was evaluated at concentrations of 10 and 50 mg/L., Triclabendazole demonstrated a fasciolicidal efficacy of 100% at a concentration of 10 and 50 mg/L at 24, 48 h and 72 hours post-treatment
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:27:01 GMT 2025
Edited
by admin
on Mon Mar 31 18:27:01 GMT 2025
Record UNII
4784C8E03O
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRICLABENDAZOLE
INN   MART.   MI  
USAN   INN  
Official Name English
FASINEX
Preferred Name English
1H-BENZIMIDAZOLE, 6-CHLORO-5-(2,3-DICHLOROPHENOXY)-2-(METHYLTHIO)-
Systematic Name English
NVP-EGA230
Code English
Triclabendazole [WHO-DD]
Common Name English
TRICLABENDAZOLE [MART.]
Common Name English
TRICLABENDAZOLE [ORANGE BOOK]
Common Name English
EGATEN
Brand Name English
triclabendazole [INN]
Common Name English
EGA230B
Code English
TRICLABENDAZOLE [MI]
Common Name English
5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole
Systematic Name English
TRICLABENDAZOLE [USAN]
Common Name English
NSC-759250
Code English
Classification Tree Code System Code
WHO-VATC QP52AC01
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
WHO-ATC P02BX04
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
FDA ORPHAN DRUG 564216
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
WHO-ESSENTIAL MEDICINES LIST 6.1.3
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
NCI_THESAURUS C250
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
FDA ORPHAN DRUG 525416
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
Code System Code Type Description
CAS
68786-66-3
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY
EVMPD
SUB11267MIG
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY
NCI_THESAURUS
C75236
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY
SMS_ID
100000092537
Created by admin on Mon Mar 31 18:27:02 GMT 2025 , Edited by admin on Mon Mar 31 18:27:02 GMT 2025
PRIMARY
MERCK INDEX
m11087
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY Merck Index
MESH
C039276
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY
DRUG CENTRAL
2734
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY
EPA CompTox
DTXSID7043952
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY
NSC
759250
Created by admin on Mon Mar 31 18:27:02 GMT 2025 , Edited by admin on Mon Mar 31 18:27:02 GMT 2025
PRIMARY
RXCUI
2118525
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY
LACTMED
Triclabendazole
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY
FDA UNII
4784C8E03O
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY
DRUG BANK
DB12245
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY
ChEMBL
CHEMBL1086440
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY
PUBCHEM
50248
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY
DAILYMED
4784C8E03O
Created by admin on Mon Mar 31 18:27:02 GMT 2025 , Edited by admin on Mon Mar 31 18:27:02 GMT 2025
PRIMARY
USAN
EF-110
Created by admin on Mon Mar 31 18:27:02 GMT 2025 , Edited by admin on Mon Mar 31 18:27:02 GMT 2025
PRIMARY
INN
5003
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY
RS_ITEM_NUM
1681611
Created by admin on Mon Mar 31 18:27:02 GMT 2025 , Edited by admin on Mon Mar 31 18:27:02 GMT 2025
PRIMARY
WIKIPEDIA
TRICLABENDAZOLE
Created by admin on Mon Mar 31 18:27:01 GMT 2025 , Edited by admin on Mon Mar 31 18:27:01 GMT 2025
PRIMARY
Related Record Type Details
CYTOCHROME P450 1A2
METABOLIC ENZYME -> SUBSTRATE
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CYTOCHROME P450 2C19
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METABOLIC ENZYME -> SUBSTRATE
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METABOLIC ENZYME -> SUBSTRATE
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CYTOCHROME P450 2D6
METABOLIC ENZYME -> SUBSTRATE
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METABOLIC ENZYME -> SUBSTRATE
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TARGET ORGANISM->INHIBITOR
CYTOCHROME P450 1A1
METABOLIC ENZYME -> SUBSTRATE
CYTOCHROME P450 1B1
METABOLIC ENZYME -> SUBSTRATE
FETAL HEPATIC FLAVIN-CONTAINING MONOOXYGENASE 3 (HUMAN)
METABOLIC ENZYME -> SUBSTRATE
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Structure of TRICLABENDAZOLE SULFONE
METABOLITE ACTIVE -> PARENT
MAJOR
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Structure of TRICLABENDAZOLE SULFOXIDE
METABOLITE ACTIVE -> PARENT
MAJOR
PLASMA
Structure of 5-CHLORO-6-(2,3-DICHLOROPHENOXY)-1H-BENZIMIDAZOLE-2-THIOL
METABOLITE -> PARENT
Related Record Type Details
Structure of TRICLABENDAZOLE SULFOXIDE
IMPURITY -> PARENT
FOR VETERINARY USE
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 4-CHLORO-5-(2,3-DICHLOROPHENOXY)-2-NITROANILINE
IMPURITY -> PARENT
FOR VETERINARY USE
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 5-CHLORO-6-(2,3-DICHLOROPHENOXY)-1H-BENZIMIDAZOLE-2-THIOL
IMPURITY -> PARENT
FOR VETERINARY USE
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of TRICLABENDAZOLE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Tmax PHARMACOKINETIC ORAL ADMINISTRATION

Biological Half-life PHARMACOKINETIC
NIH
NCATS
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