Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C7H14FNO2S |
| Molecular Weight | 194.257 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@H](CCSCCC[18F])C(O)=O
InChI
InChIKey=KAGGMRWAYDOFES-QSVFLLOFSA-N
InChI=1S/C7H14FNO2S/c8-3-1-4-12-5-2-6(9)7(10)11/h6H,1-5,9H2,(H,10,11)/t6-/m1/s1/i8-1
| Molecular Formula | C7H14FNO2S |
| Molecular Weight | 194.257 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 12:07:18 UTC 2023
by
admin
on
Sat Dec 16 12:07:18 UTC 2023
|
| Record UNII |
4G7MR2WS1V
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
C104269
Created by
admin on Sat Dec 16 12:07:18 UTC 2023 , Edited by admin on Sat Dec 16 12:07:18 UTC 2023
|
PRIMARY | |||
|
4G7MR2WS1V
Created by
admin on Sat Dec 16 12:07:18 UTC 2023 , Edited by admin on Sat Dec 16 12:07:18 UTC 2023
|
PRIMARY | |||
|
1245941-98-3
Created by
admin on Sat Dec 16 12:07:18 UTC 2023 , Edited by admin on Sat Dec 16 12:07:18 UTC 2023
|
PRIMARY | |||
|
46917699
Created by
admin on Sat Dec 16 12:07:18 UTC 2023 , Edited by admin on Sat Dec 16 12:07:18 UTC 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVE MOIETY |
RESULTS: A431 cells showed the highest (18)F-D-FPHCys uptake in vitro and in vivo followed by Colo 205, PC3 and HT-29. A similar pattern of retention was observed with (14)C-MET. (18)F-D-FPHCys retention was strongly correlated with LAT1 expression both in vitro (R(2) = 0.85) and in vivo (R(2) = 0.99). Downregulation of LAT1 by siRNA inhibited (18)F-D-FPHCys uptake, demonstrating a clear dependence on this transporter for tumour uptake. Furthermore, (18)F-D-FPHCys accumulation mirrored cellular proliferation.
CONCLUSION: The favourable properties of (18)F-D-FPHCys make this tracer a promising imaging probe for detection of tumours as well as for the noninvasive evaluation and monitoring of tumour growth.
|
||
|
ACTIVE MOIETY |
Official Title: A Phase 0 Exploratory Micro-dosing Study of S-(3-18Ffluoropropyl)Homocysteine Hydrochloride 18FFPM Using PET/CT in Patients With a Variety of Malignancies.
Purpose: The purpose of this study is to investigate the safety and potential effectiveness of the imaging compound 18F FPM for finding sites of malignancies.
|
