ATENOLOL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C14H22N2O3
Molecular Weight	266.3361
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ATENOLOL

Structure Search

SMILES

CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1

InChI

InChIKey=METKIMKYRPQLGS-UHFFFAOYSA-N

InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)

HIDE SMILES / InChI

Molecular Formula	C14H22N2O3
Molecular Weight	266.3361
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:03:17 UTC 2023` Edited by `admin` on `Sat Dec 16 18:03:17 UTC 2023`
Record UNII	50VV3VW0TI
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ATENOLOL

Official Name

English

ATENOLOL [USAN]

Common Name

English

DURAATENOLOL

Common Name

English

Atenolol [WHO-DD]

Common Name

English

ATENOLOL [USP MONOGRAPH]

Common Name

English

C07AB03

Code

English

ATENOLOL [JAN]

Common Name

English

ICI 66082

Code

English

ATENOLOL [HSDB]

Common Name

English

BENZENEACETAMIDE, 4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)-

Systematic Name

English

UROSIN

Common Name

English

ATENOLOL [VANDF]

Common Name

English

COROTENOL

Common Name

English

TENORETIC COMPONENT ATENOLOL

Common Name

English

ATENOLOL [MART.]

Common Name

English

ATENOLOL [ORANGE BOOK]

Common Name

English

ATENOLOL [EP MONOGRAPH]

Common Name

English

ATENOLOL [USP IMPURITY]

Common Name

English

JUVENTAL

Common Name

English

ATENOLOL [MI]

Common Name

English

BETACARD

Common Name

English

ATENOLOLUM [WHO-IP LATIN]

Common Name

English

ATENOLOL COMPONENT OF TENORETIC

Common Name

English

NOVATEN

Common Name

English

ATENOLOL [WHO-IP]

Common Name

English

ICI-66082

Code

English

2-(P-(HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ACETAMIDE

Systematic Name

English

MYOCORD

Common Name

English

ICI 66,082

Code

English

POLYCAP COMPONENT ATENOLOL

Brand Name

English

NSC-757832

Code

English

ATENOLOL [USP-RS]

Common Name

English

PRENORMINE

Common Name

English

2-(P-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ACETAMIDE (RACEMATE)

Systematic Name

English

atenolol [INN]

Common Name

English

TENORMIN

Brand Name

English

Classification Tree Code System Code

WHO-VATC

QC07CB53

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

LIVERTOX

NBK548379

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

WHO-ATC

C07CB53

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

WHO-VATC

QC07CB03

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

WHO-ATC

C07BB03

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

WHO-ATC

C07DB01

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

WHO-ATC

C07CB03

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

NDF-RT

N0000000161

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

NCI_THESAURUS

C29576

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

NDF-RT

N0000175556

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

WHO-VATC

QC07AB03

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

WHO-VATC

QC07BB03

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

WHO-ATC

C07FB03

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

WHO-VATC

QC07DB01

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

WHO-VATC

QC07FB03

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

WHO-ATC

C07AB03

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

Code System Code Type Description

ChEMBL

CHEMBL24

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

CHEBI

55352

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

WIKIPEDIA

ATENOLOL

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

NSC

757832

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

DAILYMED

50VV3VW0TI

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

INN

3801

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

CHEBI

2904

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

ECHA (EC/EINECS)

249-451-7

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

IUPHAR

548

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

RS_ITEM_NUM

1044403

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

CAS

29122-68-7

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

FDA UNII

50VV3VW0TI

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

MESH

D001262

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

DRUG BANK

DB00335

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

RXCUI

1202

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

RxNorm

MERCK INDEX

m2120

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

Merck Index

EVMPD

SUB05590MIG

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

NCI_THESAURUS

C28836

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

LACTMED

Atenolol

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

PUBCHEM

2249

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

HSDB

6526

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

SMS_ID

100000091183

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

DRUG CENTRAL

255

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

EPA CompTox

DTXSID2022628

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

WHO INTERNATIONAL PHARMACOPEIA

ATENOLOL

Created by admin on Sat Dec 16 18:03:20 UTC 2023 , Edited by admin on Sat Dec 16 18:03:20 UTC 2023

PRIMARY

Description: A white or almost white powder. Solubility: Sparingly soluble in water; soluble in ethanol (~750 g/l) TS; slightly soluble in dichloromethane R. Category: Cardiovascular agent; β-adrenoreceptor blocking agent. Storage: Atenolol should be kept in a tightly closed container. Requirement: Atenolol contains not less than 99.0% and not more than 101.0% of C14H22N2O3, calculated with reference to the dried substance.

Related Record Type Details


					4A4MK4KIB5

BETA-1 ADRENERGIC RECEPTOR

TARGET -> AGONIST

Interaction Type:

SHORT-ACTING

Amount:


					6DI0UT7U1Q

ATENOLOL HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					YG132I00WY

ENANTIOMER -> RACEMATE

Amount:


					DPF757BOSR

ENANTIOMER -> RACEMATE

Amount:


					U5428DG3V4

Atenolol succinate

SALT/SOLVATE -> PARENT

Amount:


					4A4MK4KIB5

BETA-1 ADRENERGIC RECEPTOR

TARGET -> INHIBITOR

Interaction Type:

BINDING

Qualification:

IC50

Amount:

Related Record Type Details


					6L3CP2R5C5

HYDROXYATENOLOL

METABOLITE LESS ACTIVE -> PARENT

Comments:

found to have only one tenth of the activity of atenolol

Interaction Type:

MINOR

Amount:

Related Record Type Details


					8UO8372UKO

N-ISOPROPYL-N,N-BIS(3-(4-(2-AMINO-2-OXOETHYL)PHENOXY)-2-HYDROXYPROP-1-YL)AMINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					Y6I8U8OX8P

METOPROLOL ACID

IMPURITY -> PARENT

Amount:


					PZ0FKL645N

DESMETHYL ATENOLOL

IMPURITY -> PARENT

Amount:


					0HY0N4ITN4

4-HYDROXYBENZENEACETAMIDE

IMPURITY -> PARENT

Amount:


					FEB0QT69BD

4-(2,3-DIHYDROXYPROPOXY)BENZENEACETAMIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					2KY735UG1A

DESISOPROPYLATENOLOL

IMPURITY -> PARENT

Amount:


					EK1PTE6GCT

2-(4-(3-CHLORO-2-HYDROXYPROPOXY)PHENYL)ACETAMIDE, (±)-

IMPURITY -> PARENT

Amount:


					1WIH2M2NY7

2,2-((2-HYDROXYPROPANE-1,3-DIYL)BIS(OXY-4,1-PHENYLENE))DIACETAMIDE

IMPURITY -> PARENT

Amount:

Related Record Type Details


					50VV3VW0TI

ATENOLOL

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC				RENAL IMPAIRMENT: CREATINE CLEARANCE LESS THAN 15 mL/min/1.73 m(2 RENAL IMPAIRMENT: CREATININE CLEARANCE 15 mL/min/1.73 m(2) to 35 mL/min/1.73 m(2)

MAXIMUM TOLERATED DOSE	TOXICITY

Tmax	PHARMACOKINETIC

ORAL BIOAVAILABILITY	PHARMACOKINETIC