Imelasomeran

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 13:26:10 GMT 2025` Edited by `admin` on `Wed Apr 02 13:26:10 GMT 2025`
Record UNII	5295LF55B6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Imelasomeran

Official Name

English

Imelasomeran [WHO-DD]

Preferred Name

English

messenger RNA (mRNA), 5?-capped, encoding a full-length, codon-optimised pre-fusion stabilised conformation variant (K983P and V984P) of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike (S) glycoprotein (Omicron variant, B.1.1.529;

Common Name

English

RNA (recombinant 5?-(m7G-(5??5?)-ppp-Gm)-capped all uridine?N1-methylpseudouridine-substituted severe acute respiratory syndrome coronavirus 2 pre-fusion spike glycoprotein B.1.1.529 variant plus 5?-and 3?-untranslated flanking region-containing poly(A)-

Common Name

English

imelasomeran [INN]

Common Name

English

Code System Code Type Description

INN

12625

Created by admin on Wed Apr 02 13:26:10 GMT 2025 , Edited by admin on Wed Apr 02 13:26:10 GMT 2025

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SMS_ID

300000043661

Created by admin on Wed Apr 02 13:26:10 GMT 2025 , Edited by admin on Wed Apr 02 13:26:10 GMT 2025

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NCI_THESAURUS

C188744

Created by admin on Wed Apr 02 13:26:10 GMT 2025 , Edited by admin on Wed Apr 02 13:26:10 GMT 2025

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FDA UNII

5295LF55B6

Created by admin on Wed Apr 02 13:26:10 GMT 2025 , Edited by admin on Wed Apr 02 13:26:10 GMT 2025

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CAS

2763208-92-8

Created by admin on Wed Apr 02 13:26:10 GMT 2025 , Edited by admin on Wed Apr 02 13:26:10 GMT 2025

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Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_4091	4091 / 4091

Linkage	Site Range	Site Count
Phosphate	1_2-1_4091	4090 / 4090

Related Record Type Details


					B6L4N5Z4GH

SARS-COV2

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					5295LF55B6

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC	U		N1-METHYLPSEUDOURIDINE	09RAD4M6WF
NUCLEOSIDE_SUBSTITUTION	[1_1]				5'-GUANOSINE-M-RNA-CAP-1-3'-PHOSPHATE	T0HQY09X7B