ERIBAXABAN

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H22ClFN4O4
Molecular Weight	484.907
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CO[C@@H]1C[C@@H](N(C1)C(=O)NC2=CC=C(Cl)C=C2)C(=O)NC3=CC=C(C=C3F)N4C=CC=CC4=O

InChI

InChIKey=QQBKAVAGLMGMHI-WIYYLYMNSA-N

InChI=1S/C24H22ClFN4O4/c1-34-18-13-21(30(14-18)24(33)27-16-7-5-15(25)6-8-16)23(32)28-20-10-9-17(12-19(20)26)29-11-3-2-4-22(29)31/h2-12,18,21H,13-14H2,1H3,(H,27,33)(H,28,32)/t18-,21-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C24H22ClFN4O4
Molecular Weight	484.907
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17683371 | https://adisinsight.springer.com/drugs/800024432 | https://www.ncbi.nlm.nih.gov/pubmed/18096830 | https://www.ncbi.nlm.nih.gov/pubmed/18392334

Eribaxaban (PD 348292) is an orally efficacious factor Xa inhibitor. It demonstrated antithrombotic efficacy in animal models. Pfizer was developing eribaxaban for the treatment of venous thrombosis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Coagulation factor X 21 Target ID: P00742 Gene ID: 2159.0 Gene Symbol: F10 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/17683371/ \| https://www.ncbi.nlm.nih.gov/pubmed/26861270	Inhibitor 8504

PubMed

Title	Date	PubMed
An adaptive-design dose-ranging study of PD 0348292, an oral factor Xa inhibitor, for thromboprophylaxis after total knee replacement surgery.	2013-08	23782955
Efficacy and toxicity of factor Xa inhibitors.	2013	23683607
Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action.	2009-03-15	19231206
Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development.	2009	19071881

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:16:56 GMT 2025` Edited by `admin` on `Wed Apr 02 09:16:56 GMT 2025`
Record UNII	5FCH6YDY7Z
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PD 348,292

Preferred Name

English

ERIBAXABAN

Official Name

English

PD-348292

Code

English

PD-348

Code

English

PD-0348292

Code

English

ERIBAXABAN [USAN]

Common Name

English

Eribaxaban [WHO-DD]

Common Name

English

eribaxaban [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C263