ADENOSINE DIPHOSPHATE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H15N5O10P2
Molecular Weight	427.2011
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O

InChI

InChIKey=XTWYTFMLZFPYCI-KQYNXXCUSA-N

InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C10H15N5O10P2
Molecular Weight	427.2011
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Potency
Purinergic receptor P2Y1 3 Target ID: CHEMBL4315 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26447940	Agonist 2752	24.0 nM [EC50]
Pyrimidinergic receptor P2Y6 7 Target ID: CHEMBL4714 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8670200	Agonist 2752	30.0 µM [EC50]
P2Y purinoceptor 13 3 Target ID: CHEMBL3321651 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12815166	Agonist 2752	308.0 nM [IC50]
Transient receptor potential cation channel subfamily M member 4 3 Target ID: CHEMBL1628469 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14758478	Inhibitor 8504	2.2 µM [IC50]

PubMed

Title	Date	PubMed
Changes in cortical and hippocampal ectonucleotidase activities in mice lacking cellular prion protein.	2001-03-23	11239719
Adhesion of adenosine diphosphate-activated platelets to human brain microvascular endothelial cells under flow in vitro is mediated via GPIIb/IIIa.	2001-03-23	11239710
[Identification and isolation of GTP-binding regulator protein from plasma membranes of oocytes from the starfish Asterias amurensis].	2001-03-10	11236575
Theoretical studies on the regulation of oxidative phosphorylation in intact tissues.	2001-03-01	11239483
Control of oxidative phosphorylation in skeletal muscle.	2001-03-01	11239481
Cross-talk between catalytic and regulatory elements in a DEAD motor domain is essential for SecA function.	2001-03-01	11230120
Methyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATP.	2001-03-01	11171113
A myosin II mutation uncouples ATPase activity from motility and shortens step size.	2001-03	11231583
The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments.	2001-03	11231582
Effect of ions and nucleotides on the interactions of yeast Rad51 protein with single-stranded oligonucleotides.	2001-03	11226888
Purification and characterization of homo- and hetero-dimeric acetate kinases from the sulfate-reducing bacterium Desulfovibrio vulgaris.	2001-03	11226881
Effects of KRN2391 on ionic currents in rabbit femoral arterial myocytes.	2001-03	11226147
GrpE accelerates peptide binding and release from the high affinity state of DnaK.	2001-03	11224572
Differential recovery of retinal function after mitochondrial inhibition by methanol intoxication.	2001-03	11222547
Molecular dynamics study of the energetic, mechanistic, and structural implications of a closed phosphate tube in ncd.	2001-03	11222280
Successful nonfreezing, subzero preservation of rat liver with 2,3-butanediol and type I antifreeze protein.	2001-03	11180993
Temporal effect of alcohol consumption on reactivity of pial arterioles: role of oxygen radicals.	2001-03	11179040
Cytochrome b(5) plays a key role in human microsomal chromium(VI) reduction.	2001-02-28	11223168
Significance of endothelial prostacyclin and nitric oxide in peripheral and pulmonary circulation.	2001-02-24	11208485
Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors.	2001-02-23	11222862
A 1.8 A resolution structure of pig muscle 3-phosphoglycerate kinase with bound MgADP and 3-phosphoglycerate in open conformation: new insight into the role of the nucleotide in domain closure.	2001-02-23	11178909
NAD+ inhibits the self-splicing of the group I intron.	2001-02-16	11178981
Adenosine diphosphate ribose dilates bovine coronary small arteries through apyrase- and 5'-nucleotidase-mediated metabolism.	2001-02-15	11173996
ADP receptor antagonists inhibit platelet aggregation induced by the chemokines SDF-1, MDC and TARC.	2001-02-09	11172816
FRET analysis indicates that the two ATPase active sites of the P-glycoprotein multidrug transporter are closely associated.	2001-02-06	11170469
Force dependence of the Michaelis constant in a two-state ratchet model for molecular motors.	2001-02-05	11178028
Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist.	2001-02-02	11166284
ADP-insensitive phosphoenzyme intermediate of sarcoplasmic reticulum Ca(2+)-ATPase has a compact conformation resistant to proteinase K, V8 protease and trypsin.	2001-02-02	11165264
Effect of gamma radiation on the in vitro aggregability of WBC-reduced apheresis platelets.	2001-02	11239229
The application of pig blood in the in vitro measurement of platelet adhesion.	2001-02	11234355
Role of ETB and B2 receptors in the ex vivo platelet inhibitory properties of endothelin and bradykinin in the mouse.	2001-02	11181435
Free ATP inhibits thimet oligopeptidase (EC 3.4.24.15) activity, induces autophosphorylation in vitro, and controls oligopeptide degradation in macrophage.	2001-02	11179954
Diazoxide protects mitochondria from anoxic injury: implications for myopreservation.	2001-02	11174735
Rapid assessment of glycoprotein IIb/IIIa blockade with the platelet function analyzer (PFA-100) during percutaneous coronary intervention.	2001-02	11174336
Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor.	2001-02	11168423
Transition state complexes of the Klebsiella pneumoniae nitrogenase proteins. Spectroscopic properties of aluminium fluoride-stabilized and beryllium fluoride-stabilized MgADP complexes reveal conformational differences of the Fe protein.	2001-02	11168422
Evidence for iterative ratcheting of receptor-bound hsp70 between its ATP and ADP conformations during assembly of glucocorticoid receptor.hsp90 heterocomplexes.	2001-01-30	11170435
Cerebroprotective action of a Na+/Ca2+ channel blocker NS-7. I. Effect on the cerebral infarction and edema at the acute stage of permanent middle cerebral artery occlusion in rats.	2001-01-26	11164779
Identification of the platelet ADP receptor targeted by antithrombotic drugs.	2001-01-11	11196645
Cardiovascular biology. Small cells, big issues.	2001-01-11	11196625
Matrix metalloproteinase 2 in tumor cell-induced platelet aggregation: regulation by nitric oxide.	2001-01-01	11196190
Increase in nuclear calcium in smooth muscle cells exposed to oxidized low density lipoprotein.	2001-01	11234999
Expression of translation initiation factors elF-4E and elF-2alpha and a potential physiologic role of continuous protein synthesis in human platelets.	2001-01	11204566
Neonatal platelet activation in preeclampsia.	2001-01	11190901
The effect of a novel glycoprotein IIb/IIIa antagonist, SR 121566A, on platelet aggregation and activation in rhesus monkeys.	2001-01	11190897
Melatonin protects fetal rat brain against oxidative mitochondrial damage.	2001-01	11168903
The C-terminal cysteine-rich region dictates specific catalytic properties in chimeras of the ectonucleotidases NTPDase1 and NTPDase2.	2001-01	11168371
Impaired platelet prostacyclin receptor activity: a monozygotic twin study discordant for spinal cord injury.	2001-01	11168298
Of mice and men: K(ATP) channels and insulin secretion.	2001	11237225
Co-transmitter function of ATP in central catecholaminergic neurons of the rat.	2001	11226696

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:54:23 GMT 2025` Edited by `admin` on `Mon Mar 31 17:54:23 GMT 2025`
Record UNII	61D2G4IYVH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ADENOSINE DIPHOSPHATE

Systematic Name

English

ADENOSINE DIPHOSPHATE [MI]

Preferred Name

English

Adenosine diphosphate [WHO-DD]

Common Name

English

ADENOSINE 5'-(TRIHYDROGEN DIPHOSPHATE)

Systematic Name

English

ADP

Common Name

English

ADENOSINE, 5'-(TRIHYDROGEN PYROPHOSPHATE)

Common Name

English

Classification Tree Code System Code

LOINC

1724-4