TANDAMINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H26N2S
Molecular Weight	302.477
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1C2=C(C=CC=C2)C3=C1C(C)(CCN(C)C)SCC3

InChI

InChIKey=BRPOADLGOFPKKJ-UHFFFAOYSA-N

InChI=1S/C18H26N2S/c1-5-20-16-9-7-6-8-14(16)15-10-13-21-18(2,17(15)20)11-12-19(3)4/h6-9H,5,10-13H2,1-4H3

HIDE SMILES / InChI

Molecular Formula	C18H26N2S
Molecular Weight	302.477
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/403562 | https://www.ncbi.nlm.nih.gov/pubmed/503251 | https://www.ncbi.nlm.nih.gov/pubmed/334686

Tandamine was developed as a selective serotonin reuptake inhibitor for the treatment of depression. Tandamine participated in clinical trials in hospitalized depressed patients, where it showed that the well-tolerated drug could be of some benefit for retarded depressions. In addition, was found in human volunteers, that tandamine possessed significant anticholinergic activity, to reduce appetite and to produce sedation. However, this drug has never been marketed.

Approval Year

PubMed

Title	Date	PubMed
Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities.	1979-09	503251
Effects of tandamine and pirandamine, selective blockers of biogenic amine uptake mechanisms, on gastric acid secretion and ulcer formation in the rat.	1977-04-15	853871
Clinical pharmacological studies of tandamine, a potential antidepressive drug.	1977-03-23	403562
The effects of tandamine, a new potential antidepressant agent, on biogenic amine uptake mechanisms and related activities.	1976-05-15	1084746
Effects of tandamine and pirandamine, new potential antidepressants, on the brain uptake of norepinephrine and 5-hydroxytryptamine and related activities.	1976-05-05	1085452

Patents

Sample Use Guides

In Vivo Use Guide

was administered in doses from 75 to 200 mg to a group of 20 hospitalized depressed patients.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:10:18 GMT 2025` Edited by `admin` on `Mon Mar 31 21:10:18 GMT 2025`
Record UNII	6L5FH5A43E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TANDAMINE

Official Name

English

tandamine [INN]

Preferred Name

English

1-(2-(DIMETHYLAMINO)ETHYL)-9-ETHYL-1,3,4,9-TETRAHYDRO-1-METHYLTHIOPYRANO(3,4-B)-INDOLE

Systematic Name

English

THIOPYRANO(3,4-B)INDOLE-1-ETHANAMINE, 9-ETHYL-1,3,4,9-TETRAHYDRO-N,N,1-TRIMETHYL-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265