Manusiran

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 18:58:02 UTC 2023` Edited by `admin` on `Sat Dec 16 18:58:02 UTC 2023`
Nucleic Acid Type	siRNA
Nucleic Acid Subtype
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	6WZ4756CFE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Manusiran

Official Name

English

manusiran [INN]

Common Name

English

RNA, (Am-sp-(2′-deoxy-2′-fluoro)A-sp-Cm-(2′-deoxy-2′-fluoro)C-Am-(2′-deoxy-2′-fluoro)G-Am-(2′-deoxy-2′-fluoro)A-Gm-(2′-deoxy-2′-fluoro)A-Am-(2′-deoxy-2′-fluoro)G-Cm-(2′-deoxy-2′-fluoro)A-Gm-(2′-deoxy-2′-fluoro)G-Um-sp-(

Common Name

English

all-P-ambo-5'-O-{21-[(2-acetamido-2-deoxy-β-D -galactopyranosyl)oxy]-9,9-bis{12-[(2-acetamido-2-deoxy-β-D -galactopyranosyl)oxy]-7-hydroxy-7-sulfanylidene-2,6,8-trioxa-7λ 5 -phosphadodecan-1-yl}-1,16-dihydroxy-1,16-bis(sulfanylidene)-2,7,11,15,17-pent

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C190363

Created by admin on Sat Dec 16 18:58:02 UTC 2023 , Edited by admin on Sat Dec 16 18:58:02 UTC 2023

PRIMARY

CAS

2646704-10-9

Created by admin on Sat Dec 16 18:58:02 UTC 2023 , Edited by admin on Sat Dec 16 18:58:02 UTC 2023

PRIMARY

INN

12371

Created by admin on Sat Dec 16 18:58:02 UTC 2023 , Edited by admin on Sat Dec 16 18:58:02 UTC 2023

PRIMARY

FDA UNII

6WZ4756CFE

Created by admin on Sat Dec 16 18:58:02 UTC 2023 , Edited by admin on Sat Dec 16 18:58:02 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_2;1_4;1_6;1_8;1_10;1_12;1_14;1_16;1_18;2_1;2_3;2_5;2_7;2_9;2_11;2_13;2_15;2_17;2_19	19 / 38
2'-O-Methyl-Ribose	1_1;1_3;1_5;1_7;1_9;1_11;1_13;1_15;1_17;1_19;2_2;2_4;2_6;2_8;2_10;2_12;2_14;2_16;2_18	19 / 38

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_3;1_18-1_19;2_18-2_19	6 / 36
Phosphate	1_4-1_17;2_2-2_17	30 / 36

Related Record Type Details


					7OG8I08TRT

TRANSMEMBRANE PROTEASE SERINE 6

TARGET->INHIBITOR OF EXPRESSION

Amount:

Related Record Type Details


					6WZ4756CFE

Manusiran

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[2_1]	5'-TERMINUS			UNSPECIFIED SUBSTANCE	24e955a9 (not in database)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL