(2-CHLOROPHENYL)DIPHENYLMETHANOL

OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3Cl

InChIKey=KTVAHLGKTSPDOG-UHFFFAOYSA-N

InChI=1S/C19H15ClO/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14,21H

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
calcium-activated potassium channel activity 3 Target ID: GO:0015269 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9151659 \| https://www.ncbi.nlm.nih.gov/pubmed/11181430	Inhibitor 8504
Slow afterhyperpolarization 1 Target ID: Slow afterhyperpolarization Sources: https://www.ncbi.nlm.nih.gov/pubmed/11181430	Inhibitor 8504	2.2 µM [IC50]
High voltage-activated (HVA) Ca2+ current 1 Target ID: High voltage-activated (HVA) Ca2+ current Sources: https://www.ncbi.nlm.nih.gov/pubmed/11181430	Inhibitor 8504	2.2 µM [IC50]

PubMed

Title	Date	PubMed
Space-filling trialkoxysilane: synthesis and self-assembly into low-density monolayers.	2010-12-21	21090761
Influence of ionising irradiation on clotrimazole in the solid state.	2009-11-01	18930367
Development and validation of HPLC method for determination of clotrimazole and its two degradation products in spray formulation.	2007-09-30	19073060
Production and characterization of hot-melt extruded films containing clotrimazole.	2003-08	12906333
Tritylamino aromatic heterocycles and related carbinols as blockers of ca 2+-activated potassium ion channels underlying neuronal hyperpolarization.	2002-04	12112036
Clotrimazole analogues: effective blockers of the slow afterhyperpolarization in cultured rat hippocampal pyramidal neurones.	2001-02	11181430

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:31:45 GMT 2025` Edited by `admin` on `Mon Mar 31 22:31:45 GMT 2025`
Record UNII	77N69DJ59Q
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

TRAM 3

Preferred Name

English

(2-CHLOROPHENYL)DIPHENYLMETHANOL

Systematic Name

English

CLOTRIMAZOLE RELATED COMPOUND A [USP-RS]

Common Name

English

O-CHLOROPHENYLDIPHENYLMETHANOL

Systematic Name

English

NSC-170882

Code

English

CLOTRIMAZOLE IMPURITY A [EP IMPURITY]

Common Name

English

BENZENEMETHANOL, 2-CHLORO-.ALPHA.,.ALPHA.-DIPHENYL-

Systematic Name

English

Code System Code Type Description

NSC

170882