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Details

Stereochemistry ACHIRAL
Molecular Formula C29H33ClN2O2.ClH
Molecular Weight 513.498
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LOPERAMIDE HYDROCHLORIDE

SMILES

Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)C2=CC=C(Cl)C=C2)(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=PGYPOBZJRVSMDS-UHFFFAOYSA-N
InChI=1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H

HIDE SMILES / InChI
Molecular Formula C29H33ClN2O2
Molecular Weight 477.038
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
123738
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:35:00 UTC 2023
Edited
by admin
on Fri Dec 15 15:35:00 UTC 2023
Record UNII
77TI35393C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LOPERAMIDE HYDROCHLORIDE
EP   JAN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
USAN  
Official Name English
LOPERAMIDE HYDROCHLORIDE [USP-RS]
Common Name English
LOPERAMIDE HYDROCHLORIDE COMPONENT OF IMODIUM MULTI-SYMPTOM RELIEF
Common Name English
R 18,553
Code English
LOPERAMIDE HYDROCHLORIDE [USP MONOGRAPH]
Common Name English
LOPERAMIDE HYDROCHLORIDE [EP MONOGRAPH]
Common Name English
1-PIPERIDINEBUTANAMIDE, 4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-.ALPHA.,.ALPHA.-DIPHENYL-, MONOHYDROCHLORIDE
Common Name English
LOPERAMIDE HYDROCHLORIDE [MI]
Common Name English
LOPERAMIDE HYDROCHLORIDE [VANDF]
Common Name English
LOPERAMIDI HYDROCHLORIDUM [WHO-IP LATIN]
Common Name English
R-18553
Code English
LOPERAMIDE HYDROCHLORIDE [MART.]
Common Name English
LOPERAMIDE HYDROCHLORIDE [WHO-IP]
Common Name English
LOPERAMIDE HYDROCHLORIDE [ORANGE BOOK]
Common Name English
LOPERAMIDE HCL
Common Name English
NSC-696356
Code English
LOPERAMIDE HYDROCHLORIDE [USAN]
Common Name English
Loperamide hydrochloride [WHO-DD]
Common Name English
LOPERAMIDE HYDROCHLORIDE [EP IMPURITY]
Common Name English
4-(P-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-.ALPHA.,.ALPHA.-DIPHENYL-1-PIPERIDINEBUTYRAMIDE MONOHYDROCHLORIDE
Common Name English
LOPERAMIDE HYDROCHLORIDE [JAN]
Common Name English
IMODIUM
Brand Name English
IMODIUM MULTI-SYMPTOM RELIEF COMPONENT LOPERAMIDE HYDROCHLORIDE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C266
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
Code System Code Type Description
DRUG BANK
DBSALT000709
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY
EVMPD
SUB02969MIG
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
LOPERAMIDE HYDROCHLORIDE
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY Description: A white to slightly yellowish powder. Solubility: Slightly soluble in water and in dilute acids; freely soluble in methanol R. Category: Antidiarrhoeal drug. Storage: Loperamide hydrochloride should be kept in a well-closed container. Definition: Loperamide hydrochloride contains not less than 98.0% and not more than 102.0% of C29H33ClN2O2,HCl, calculated with reference to the dried substance.
CHEBI
6533
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY
SMS_ID
100000090166
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY
PUBCHEM
71420
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY
NSC
696356
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY
FDA UNII
77TI35393C
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY
MERCK INDEX
m6898
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY Merck Index
DAILYMED
77TI35393C
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY
EPA CompTox
DTXSID00880006
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY
RS_ITEM_NUM
1370000
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY
RXCUI
82038
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY RxNorm
CAS
34552-83-5
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY
NCI_THESAURUS
C1584
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY
ChEMBL
CHEMBL841
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY
ECHA (EC/EINECS)
252-082-4
Created by admin on Fri Dec 15 15:35:00 UTC 2023 , Edited by admin on Fri Dec 15 15:35:00 UTC 2023
PRIMARY
Related Record Type Details
Structure of LOPERAMIDE
PARENT -> SALT/SOLVATE
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Structure of 4-(4-CHLOROPHENYL)-4-PIPERIDINOL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of LOPERAMIDE OXIDE, CIS-
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 4-(4-CHLOROPHENYL)-1,1-BIS(4-(DIMETHYLAMINO)-4-OXO-3,3-DIPHENYLBUTYL)-4-HYDROXYPIPERIDINIUM
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 4-(4-CHLOROPHENYL)-1-(4-(4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDIN-1-YL)-2,2-DIPHENYLBUTANOYL)PIPERIDIN-4-OL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of R-18936
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.7
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 4-(4-(4-CHLOROPHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL)-N,N-DIMETHYL-2,2-DIPHENYLBUTANAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 4-DECHLORO-4-(4-CHLOROPHENYL) LOPERAMIDE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.3
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of LOPERAMIDE OXIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of LOPERAMIDE
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