MOTACABTAGENE LUREVGEDLEUCEL

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 10:49:49 GMT 2025` Edited by `admin` on `Wed Apr 02 10:49:49 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Name	t cells
Record UNII	7CH7MR6SN5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ALLOGENEIC T CELLS OBTAINED FROM PERIPHERAL BLOOD BY LEUKAPHERESIS, GENETICALLY MODIFIED BY CRISPR/CAS9 (CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS/CRISPR-ASSOCIATED PROTEIN 9) MEDIATED GENE EDITING CONSISTING OF TWO GUIDE RNAS (GRNAS) INT

Preferred Name

English

MOTACABTAGENE LUREVGEDLEUCEL

Official Name

English

motacabtagene lurevgedleucel [INN]

Common Name

English

Code System Code Type Description

INN

11721

Created by admin on Wed Apr 02 10:49:49 GMT 2025 , Edited by admin on Wed Apr 02 10:49:49 GMT 2025

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FDA UNII

7CH7MR6SN5

Created by admin on Wed Apr 02 10:49:49 GMT 2025 , Edited by admin on Wed Apr 02 10:49:49 GMT 2025

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SMS_ID

300000005385

Created by admin on Wed Apr 02 10:49:49 GMT 2025 , Edited by admin on Wed Apr 02 10:49:49 GMT 2025

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NCI_THESAURUS

C172741

Created by admin on Wed Apr 02 10:49:49 GMT 2025 , Edited by admin on Wed Apr 02 10:49:49 GMT 2025

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Related Record Type Details


					PK6VHJAIBD

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					7CH7MR6SN5

MOTACABTAGENE LUREVGEDLEUCEL

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Fragment Name	Fragment ID
CRISPR	GENE TRUNCATION	EVONCABTAGENE PAZURGEDLEUCEL SINGLE GUIDE RNA (SGRNA) TARGETING THE TRAC LOCUS	FKP72X9XKK
	TRANSFECTION	MOTACABTAGENE LUREVGEDLEUCEL VECTOR	B2W33RXV75
CULTURE	EXPANSION	HUMAN INTERLEUKIN-2	FNO32LO217
CULTURE	EXPANSION	INTERLEUKIN-7 HUMAN RECOMBINANT	418XB47Y71
CRISPR	GENE TRUNCATION	EVONCABTAGENE PAZURGEDLEUCEL SINGLE GUIDE RNA (SGRNA) TARGETING THE .BETA.2M LOCUS	EQW8RVL4CV

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					MOTACABTAGENE LUREVGEDLEUCEL EXPRESSED CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING B-CELL MATURATION ANTIGEN (BCMA)	A9SFR34QU8
INSERTED GENE EXPRESSION VECTOR					MOTACABTAGENE LUREVGEDLEUCEL TRANSGENE INSERT	5AX55JEG65