NAVTEMADLIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C28H35Cl2NO5S
Molecular Weight	568.552
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)[C@@H](CS(=O)(=O)C(C)C)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)C2=CC(Cl)=CC=C2)C3=CC=C(Cl)C=C3

InChI

InChIKey=DRLCSJFKKILATL-YWCVFVGNSA-N

InChI=1S/C28H35Cl2NO5S/c1-17(2)24(16-37(35,36)18(3)4)31-26(19-9-11-21(29)12-10-19)23(20-7-6-8-22(30)13-20)14-28(5,27(31)34)15-25(32)33/h6-13,17-18,23-24,26H,14-16H2,1-5H3,(H,32,33)/t23-,24-,26-,28-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C28H35Cl2NO5S
Molecular Weight	568.552
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:01:54 UTC 2023` Edited by `admin` on `Sat Dec 16 08:01:54 UTC 2023`
Record UNII	7R7G6EH5UL
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

NAVTEMADLIN

Official Name

English

MDM2 INHIBITOR AMG-232

Common Name

English

3-Piperidineacetic acid, 5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-2-methyl-1-[[(1-methylethyl)sulfonyl]methyl]propyl]-2-oxo-, (3R,5R,6S)-

Systematic Name

English

AMG 232 [WHO-DD]

Common Name

English

2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Systematic Name

English

NAVTEMADLIN [USAN]

Common Name

English

navtemadlin [INN]

Common Name

English

{(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3- methyl-1-[(2S)-3-methyl-1-(propane-2-sulfonyl)butan2-yl]-2-oxopiperidin-3-yl}acetic acid

Systematic Name

English

AMG-232

Code

English

KRT-232

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

735120