DEACETYLDILTIAZEM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H24N2O3S
Molecular Weight	372.481
Optical Activity	( + )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)[C@@H]2SC3=C(C=CC=C3)N(CCN(C)C)C(=O)[C@@H]2O

InChI

InChIKey=NZHUXMZTSSZXSB-MOPGFXCFSA-N

InChI=1S/C20H24N2O3S/c1-21(2)12-13-22-16-6-4-5-7-17(16)26-19(18(23)20(22)24)14-8-10-15(25-3)11-9-14/h4-11,18-19,23H,12-13H2,1-3H3/t18-,19+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C20H24N2O3S
Molecular Weight	372.481
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
The role of calcium antagonists in chronic kidney disease.	2004-03	15202609
Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites.	2002-10	12419016
Pharmacokinetic interaction between tacrolimus and diltiazem: dose-response relationship in kidney and liver transplant recipients.	2002	12036394
Slowing the progression of renal disease in diabetic patients.	2001-04	11302410
Effects of diltiazem on down-regulation of lymphocyte beta-adrenoceptors in patients with chronic congestive heart failure.	2000-10	11501046
An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation.	2000-09	10950845
The effect of calcium channel blockers on cerebral oxygenation during tracheal extubation.	2000-08	10910846
Effects of diltiazem retard on ambulatory blood pressure and heart rate variability in patients with essential hypertension.	2000-06	10915232
The interaction of diltiazem with simvastatin.	2000-03	10741630
Increased urinary cortisol and androgen metabolites in a young female with hypertension: partial glucocorticoid resistance syndrome.	2000	10894920
Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug.	1999-04	10320950
Probable diltiazem-induced acute interstitial nephritis.	1998-06	9640485
Lower incidence of liver graft rejection in patients on diltiazem plus cyclosporine therapy.	1998-06	9636582
Relative bioavailability of Cardizem CD and Tiazac controlled-release diltiazem dosage forms after single and multiple dosing in healthy volunteers.	1998-05	10099056
[Effect of diltiazem on concentration of cyclosporin metabolites in Sandimmune and Neoral treated kidney transplant patients].	1997-10-15	9446006
Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix.	1996-05-28	8643600
Inhibitory effects of TA-993, a new 1,5-benzothiazepine derivative, on platelet aggregation.	1996-04	8635222
Anaphylatoxin C3a induces rapid protein phosphorylation in guinea pig platelets.	1994-09-01	8002292
Effect of diltiazem and low-dose aspirin on platelet aggregation and ATP release induced by paired agonists.	1993-08-02	8236144
The influence of diltiazem versus cimetidine on propranolol metabolism.	1992-12	1487547

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:24:01 GMT 2025` Edited by `admin` on `Mon Mar 31 18:24:01 GMT 2025`
Record UNII	849UT193YJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DEACETYLDILTIAZEM

Common Name

English

DESACETYLDILTIAZEM

Preferred Name

English

DILTIAZEM HYDROCHLORIDE IMPURITY F [EP IMPURITY]

Common Name

English

1,5-BENZOTHIAZEPIN-4(5H)-ONE, 5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-, (2S,3S)-

Systematic Name

English

(+)-DESACETYLDILTIAZEM

Common Name

English

DEACETYL-D-DILTIAZEM

Common Name

English

Desacetyldiltiazem [WHO-DD]

Common Name

English

DESACETYLDILTIAZEM [WHO-IP]

Common Name

English

Code System Code Type Description

PUBCHEM

91638