Zotresiran

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 18:15:35 GMT 2025` Edited by `admin` on `Wed Apr 02 18:15:35 GMT 2025`
Nucleic Acid Type	dsRNA
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	88X9BPQ5N4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RNA, (Am-sp-(2?-deoxy-2?-fluoro)C-sp-Um-Cm-Gm-(2?-deoxy-2?-fluoro)U-Um-Cm-Cm-Am-Um-Am-Am-(2?-deoxy-2?-fluoro)U-Am-(2?-deoxy-2?-fluoro)C-Um-Cm-Um-Gm-Am-sp-Gm-sp-Am), complex with RNA (Um-sp-Cm-sp-Am-Gm-Am-Gm-(2?-deoxy-2?-fluoro)U-Am-(2?-deoxy-2?-fluoro)U-

Preferred Name

English

Zotresiran

Official Name

English

zotresiran [INN]

Common Name

English

Code System Code Type Description

CAS

2756821-85-7

Created by admin on Wed Apr 02 18:15:35 GMT 2025 , Edited by admin on Wed Apr 02 18:15:35 GMT 2025

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FDA UNII

88X9BPQ5N4

Created by admin on Wed Apr 02 18:15:35 GMT 2025 , Edited by admin on Wed Apr 02 18:15:35 GMT 2025

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NCI_THESAURUS

C203140

Created by admin on Wed Apr 02 18:15:35 GMT 2025 , Edited by admin on Wed Apr 02 18:15:35 GMT 2025

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INN

12656

Created by admin on Wed Apr 02 18:15:35 GMT 2025 , Edited by admin on Wed Apr 02 18:15:35 GMT 2025

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Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_6;1_14;1_16;2_7;2_9-2_11	7 / 44
2'-O-Methyl-Ribose	1_1-1_5;1_7-1_13;1_15;1_17-1_23;2_1-2_6;2_8;2_12-2_21	37 / 44

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_3;1_22-1_23;2_2-2_3	6 / 42
Phosphate	1_4-1_21;2_4-2_21	36 / 42

Related Record Type Details


					ATA6VBL43H

XANTHINE DEHYDROGENASE/OXIDASE

TARGET->INHIBITOR OF EXPRESSION

Amount:

Related Record Type Details


					88X9BPQ5N4

Zotresiran

ACTIVE MOIETY

Comments:

xanthine dehydrogenase synthesis reducer

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[2_21]	3'-TERMINUS			UNSPECIFIED SUBSTANCE	c6b500e6 (not in database)