IZOKIBEP

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 23:21:46 GMT 2025` Edited by `admin` on `Tue Apr 01 23:21:46 GMT 2025`
Protein Type	FUSION PROTEINS
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	8B8VV1W6FZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IZOKIBEP

Official Name

English

ABY035

Preferred Name

English

Izokibep [WHO-DD]

Common Name

English

ABY-035/AFO2

Common Name

English

FUSION PROTEIN COMPOSED OF 3 BINDING DOMAINS CONSISTING OF THREE-ALPHA-HELIX MOTIFS, EACH DERIVED FROM THE IMMUNOGLOBULIN (IG)-BINDING Z-DOMAIN OF STAPHYLOCOCCAL PROTEIN A (SPA), ENGINEERED FOR BINDING TO TWO HOMODIMER SUBUNITS OF HUMAN INTERLEUKIN 17A (

Common Name

English

IZOKIBEP [USAN]

Common Name

English

AFFIBODY ABY-035 (RECOMBINANT HUMAN INTERLEUKIN 17A-BINDING)

Common Name

English

IMG-020

Code

English

izokibep [INN]

Common Name

English

ABY-035

Code

English

Code System Code Type Description

FDA UNII

8B8VV1W6FZ

Created by admin on Tue Apr 01 23:21:46 GMT 2025 , Edited by admin on Tue Apr 01 23:21:46 GMT 2025

PRIMARY

USAN

JK-250

Created by admin on Tue Apr 01 23:21:46 GMT 2025 , Edited by admin on Tue Apr 01 23:21:46 GMT 2025

PRIMARY

CAS

2226130-02-3

Created by admin on Tue Apr 01 23:21:46 GMT 2025 , Edited by admin on Tue Apr 01 23:21:46 GMT 2025

PRIMARY

NCI_THESAURUS

C175101

Created by admin on Tue Apr 01 23:21:46 GMT 2025 , Edited by admin on Tue Apr 01 23:21:46 GMT 2025

PRIMARY

SMS_ID

300000004201

Created by admin on Tue Apr 01 23:21:46 GMT 2025 , Edited by admin on Tue Apr 01 23:21:46 GMT 2025

PRIMARY

INN

11121

Created by admin on Tue Apr 01 23:21:46 GMT 2025 , Edited by admin on Tue Apr 01 23:21:46 GMT 2025

PRIMARY

Related Record Type Details


					R44E6C7B6J

INTERLEUKIN-17A

TARGET -> INHIBITOR

Amount:


					ZIF514RVZR

BINDER->LIGAND

Comments:

Fusion of an albumin binding domain in between the two IL-17A binding Affibody domains increases the molecule’s plasma half-life.

Interaction Type:

BINDING

Amount:

Related Record Type Details


					8B8VV1W6FZ

IZOKIBEP

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL