OLMESARTAN

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H26N6O3
Molecular Weight	446.5016
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of OLMESARTAN

Structure Search

SMILES

CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=C(C=CC=C3)C4=NN=NN4)C(O)=O)C(C)(C)O

InChI

InChIKey=VTRAEEWXHOVJFV-UHFFFAOYSA-N

InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)

HIDE SMILES / InChI

Molecular Formula	C24H26N6O3
Molecular Weight	446.5016
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:54:30 UTC 2023` Edited by `admin` on `Sat Dec 16 17:54:30 UTC 2023`
Record UNII	8W1IQP3U10
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

OLMESARTAN

Official Name

English

Olmesartan [WHO-DD]

Common Name

English

olmesartan [INN]

Common Name

English

NSC-759810

Code

English

OLMESARTAN [MI]

Common Name

English

OLMESARTAN MEDOXOMIL IMPURITY A [EP IMPURITY]

Common Name

English

OLMESARTAN MEDOXOMIL IMPURITY, OLMESARTAN- [USP IMPURITY]

Common Name

English

RNH-6270

Code

English

OLMESARTAN [USAN]

Common Name

English

1H-IMIDAZOLE-5-CARBOXYLIC ACID, 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1-((2'-(1H-TETRAZOL-5-YL) (1,1'-BIPHENYL)-4-YL)METHYL)-

Common Name

English

OLMESARTAN [VANDF]

Common Name

English

Classification Tree Code System Code

WHO-ATC

C09DB02

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

NDF-RT

N0000175561

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

NCI_THESAURUS

C66930

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

LIVERTOX

NBK548153

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

NDF-RT

N0000000070

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

Code System Code Type Description

ChEMBL

CHEMBL1516

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

DRUG BANK

DB00275

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

NCI_THESAURUS

C66253

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

NSC

759810

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

HSDB

8214

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

PUBCHEM

158781

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

SMS_ID

100000086475

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

WIKIPEDIA

OLMESARTAN

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

CAS

144689-24-7

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

RXCUI

321064

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

RxNorm

IUPHAR

591

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

FDA UNII

8W1IQP3U10

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

INN

8612

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

MERCK INDEX

m8203

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

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Merck Index

EVMPD

SUB20707

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

DAILYMED

8W1IQP3U10

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

USAN

NN-36

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

MESH

C437965

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

LACTMED

Olmesartan

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

EPA CompTox

DTXSID2040571

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

CHEBI

48416

Created by admin on Sat Dec 16 17:54:32 UTC 2023 , Edited by admin on Sat Dec 16 17:54:32 UTC 2023

PRIMARY

Related Record Type Details


					I81U7H57XI

OAT-1

TRANSPORTER -> INHIBITOR


					DJD559V57Z

OLMESARTAN MONOHYDRATE

SALT/SOLVATE -> PARENT


					056QD38ZSG

TYPE-1 ANGIOTENSIN II RECEPTOR

TARGET -> INHIBITOR

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					848C605P1X

CYTOCHROME P450 2J2

METABOLIC ENZYME -> INHIBITOR

Comments:

As there is almost a negligible accumulation of olmesartan ain the liver it is thought not to inhibit the production of eicosanoids.

Qualification:

IC50

Amount:


					L9DP834D1P

CYTOCHROME P450 2C9

METABOLIC ENZYME -> INHIBITOR

Comments:

As there is almost a negligible accumulation of olmesartan ain the liver it is thought not to inhibit the production of eicosanoids.

Qualification:

IC50

Amount:


					DJD559V57Z

OLMESARTAN MONOHYDRATE

SOLVATE->ANHYDROUS


					4HZ67LW8L7

OAT-4

TRANSPORTER -> INHIBITOR


					ZWJ2Y6JZWY

OAT-3

TRANSPORTER -> INHIBITOR

Related Record Type Details


					7278M3VQA8

Olmesartan cilexetil

PRODRUG -> METABOLITE ACTIVE

Amount:


					6M97XTV3HD

OLMESARTAN MEDOXOMIL

PRODRUG -> METABOLITE ACTIVE

Related Record Type Details


					M43H21IO8R

N-NITROSODIMETHYLAMINE

IMPURITY GENOTOXIC->PARENT

Comments:

NDMA is an organic chemical that is in a family of potent carcinogens.

Amount:


					6M97XTV3HD

OLMESARTAN MEDOXOMIL

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					3IQ78TTX1A

N-NITROSODIETHYLAMINE

IMPURITY -> PARENT

Comments:

Probable human carcinogen.

Amount:


					H81CGI9K6Z

BENZYL(METHYL)NITROSAMINE

IMPURITY -> PARENT

Comments:

Priority toxic pollutant.

Amount:

Related Record Type Details


					8W1IQP3U10

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC