Nesfrotamig

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 20:28:58 GMT 2025` Edited by `admin` on `Wed Apr 02 20:28:58 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	BISPECIFIC T CELL ENGAGER\|IGG1\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	8YNA3QG3DS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Nesfrotamig

Official Name

English

ABL-105

Preferred Name

English

YH32367

Code

English

H-gamma1 heavy chain anti-ERBB2 fused to a scFvlh anti-TNFRSF9 (1-719) [H-gamma1 heavy chain anti-ERBB2 humanized (1-450) [VH (Homo sapiens IGHV3-66*01 (81.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120)-Homo sapiens IGHG1*0

Common Name

English

Immunoglobulin G1, bispecific, anti-(human/Macaca fascicularis epidermal growth factor receptor HER2) (human-Mus musculus monoclonal YH32367 ?1-chain) fusion protein with peptide linker ((GS)9) fusion protein with immunoglobulin anti-(human/Macaca fascic

Common Name

English

HER2/4-1BB bispecific antibody, YH32367

Common Name

English

nesfrotamig [INN]

Common Name

English

ABL105

Code

English

YH-32367

Code

English

immunoglobulin (H-gamma1-scFvlh_L-kappa) dimer, anti-[Homo sapiens ERBB2 (receptor tyrosine-protein kinase erbB-2, epidermal growth factor receptor 2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)] and anti-[Homo sapiens TNFRSF9 (TNF receptor superfamily

Common Name

English

Code System Code Type Description

INN

13381

Created by admin on Wed Apr 02 20:28:58 GMT 2025 , Edited by admin on Wed Apr 02 20:28:58 GMT 2025

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CAS

2966936-23-0

Created by admin on Wed Apr 02 20:28:58 GMT 2025 , Edited by admin on Wed Apr 02 20:28:58 GMT 2025

PRIMARY

NCI_THESAURUS

C192011

Created by admin on Wed Apr 02 20:28:58 GMT 2025 , Edited by admin on Wed Apr 02 20:28:58 GMT 2025

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FDA UNII

8YNA3QG3DS

Created by admin on Wed Apr 02 20:28:58 GMT 2025 , Edited by admin on Wed Apr 02 20:28:58 GMT 2025

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From	To
4_23	4_88
4_134	4_194
3_134	3_194
3_23	3_88
2_642	2_694
2_571	2_620
2_490	2_557
2_370	2_428
2_264	2_324
2_223	4_214
2_147	2_203
2_22	2_96
1_642	1_694
1_571	1_620
1_490	1_557
1_370	1_428
1_264	1_324
1_232	2_232
1_229	2_229
1_223	3_214
1_147	1_203
1_22	1_96