PASIREOTIDE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C58H66N10O9
Molecular Weight	1047.2062
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PASIREOTIDE

Structure Search

SMILES

[H][C@@]12C[C@H](CN1C(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(OCC5=CC=CC=C5)C=C4)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC6=CNC7=C6C=CC=C7)NC(=O)[C@@H](NC2=O)C8=CC=CC=C8)OC(=O)NCCN

InChI

InChIKey=VMZMNAABQBOLAK-DBILLSOUSA-N

InChI=1S/C58H66N10O9/c59-27-13-12-22-46-52(69)64-47(30-38-23-25-42(26-24-38)76-36-39-16-6-2-7-17-39)53(70)66-49(31-37-14-4-1-5-15-37)57(74)68-35-43(77-58(75)61-29-28-60)33-50(68)55(72)67-51(40-18-8-3-9-19-40)56(73)65-48(54(71)63-46)32-41-34-62-45-21-11-10-20-44(41)45/h1-11,14-21,23-26,34,43,46-51,62H,12-13,22,27-33,35-36,59-60H2,(H,61,75)(H,63,71)(H,64,69)(H,65,73)(H,66,70)(H,67,72)/t43-,46+,47+,48-,49+,50+,51+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C58H66N10O9
Molecular Weight	1047.2062
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:47:27 UTC 2023` Edited by `admin` on `Sat Dec 16 16:47:27 UTC 2023`
Record UNII	98H1T17066
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PASIREOTIDE

Official Name

English

pasireotide [INN]

Common Name

English

CYCLO((4R)-4-(2-AMINOETHYLCARBAMOYLOXY)-L-PROLYL-L-PHENYLGLYCYL-D-TRYPTOPHYL-L-LYSYL-4-O-BENZYL-L-TYROSYL-L-PHENYLALANYL-)

Common Name

English

PASIREOTIDE [VANDF]

Common Name

English

PASIREOTIDE [MI]

Common Name

English

PASIREOTIDE [MART.]

Common Name

English

SOM230

Code

English

Pasireotide [WHO-DD]

Common Name

English

PASIREOTIDE [USAN]

Common Name

English

SOM-230

Code

English

Classification Tree Code System Code

WHO-VATC

QH01CB05

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

NCI_THESAURUS

C62799

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

EU-Orphan Drug

EU/3/09/671

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

FDA ORPHAN DRUG

188804

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

FDA ORPHAN DRUG

288709

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

NDF-RT

N0000175904

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

EMA ASSESSMENT REPORTS

SIGNIFOR (AUTHORIZED: ACROMEGALY, PITUITARY ACTH HYPERSECRETION)

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

WHO-ATC

H01CB05

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

FDA ORPHAN DRUG

288609

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

Code System Code Type Description

MESH

C517782

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

DRUG BANK

DB06663

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

DRUG CENTRAL

4329

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

PUBCHEM

9941444

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

IUPHAR

2018

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

CHEBI

72313

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

CAS

396091-73-9

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

EVMPD

SUB31564

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

INN

8384

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

ChEMBL

CHEMBL3039583

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

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LACTMED

Pasireotide

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

NCI_THESAURUS

C69131

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

SMS_ID

100000124200

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

CHEBI

72312

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

DAILYMED

98H1T17066

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

WIKIPEDIA

PASIREOTIDE

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

FDA UNII

98H1T17066

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

EPA CompTox

DTXSID501026040

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

MERCK INDEX

m8425

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

Merck Index

RXCUI

1364105

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

RxNorm

USAN

YY-117

Created by admin on Sat Dec 16 16:47:28 UTC 2023 , Edited by admin on Sat Dec 16 16:47:28 UTC 2023

PRIMARY

Related Record Type Details


					6E20216Q0L

PARENT -> DERIVATIVE

Amount:


					I4P76SY3N4

PASIREOTIDE DIASPARTATE

SALT/SOLVATE -> PARENT

Amount:


					04F55A7UZ3

PASIREOTIDE PAMOATE

SALT/SOLVATE -> PARENT

Amount:


					G49RZO51ZC

OATP-B

TRANSPORTER -> NON-SUBSTRATE

Amount:


					8X85ZJG6XJ

SOMATOSTATIN RECEPTOR TYPE 5

TARGET -> AGONIST

Amount:


					662X0VFR9L

PASIREOTIDE ACETATE

SALT/SOLVATE -> PARENT

Amount:


					76UB6O122H

ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2

TRANSPORTER -> NON-SUBSTRATE

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> INHIBITOR

Amount:


					0RFO7VC96N

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1

METABOLIC ENZYME -> NON-SUBSTRATE

Comments:

in vitro study results indicate that pasireotide is not a substrate, inhibitor, or inducer for metabolic isozymes including UGT1A1 particularly at the proposed dosing range.

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE

Amount:


					AIN96D6SGL

OATP1B1

TRANSPORTER -> NON-SUBSTRATE

Amount:


					66DDF797LP

OATP-8

TRANSPORTER -> NON-SUBSTRATE

Amount:

Related Record Type Details


					98H1T17066

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				SC INJECTION

Biological Half-life	PHARMACOKINETIC