Turenkibart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 19:58:38 GMT 2025` Edited by `admin` on `Wed Apr 02 19:58:38 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	A2X6JB3B7U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

H-gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV1-69-2*01 (86.5%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, G1v78 CH3 L107, A114 (CH1 K120 (215) (119-216

Preferred Name

English

Turenkibart

Official Name

English

Immunoglobulin G1 [429-leucine,435-alanine], anti-(human interleukin 17A) (human-Mus musculus monoclonal SCT650C ?1-chain), disulfide with human-Mus musculus monoclonal SCT650C ?-chain, dimer

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens IL17A (Interleukin 17A, IL-17), humanized monoclonal antibody

Common Name

English

turenkibart [INN]

Common Name

English

Code System Code Type Description

CAS

2761187-73-7

Created by admin on Wed Apr 02 19:58:38 GMT 2025 , Edited by admin on Wed Apr 02 19:58:38 GMT 2025

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NCI_THESAURUS

C211753

Created by admin on Wed Apr 02 19:58:38 GMT 2025 , Edited by admin on Wed Apr 02 19:58:38 GMT 2025

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FDA UNII

A2X6JB3B7U

Created by admin on Wed Apr 02 19:58:38 GMT 2025 , Edited by admin on Wed Apr 02 19:58:38 GMT 2025

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SMS_ID

300000056828

Created by admin on Wed Apr 02 19:58:38 GMT 2025 , Edited by admin on Wed Apr 02 19:58:38 GMT 2025

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INN

12621

Created by admin on Wed Apr 02 19:58:38 GMT 2025 , Edited by admin on Wed Apr 02 19:58:38 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_145	2_201
2_221	4_220
2_262	2_322
1_145	1_201
2_368	2_426
3_23	3_94
3_140	3_200
4_23	4_94
4_140	4_200
1_221	3_220
1_227	2_227
1_230	2_230
1_262	1_322
1_368	1_426

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298
N	3_31
N	4_31

Related Record Type Details


					R44E6C7B6J

INTERLEUKIN-17A

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					A2X6JB3B7U

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_448] [2_448]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL