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Details

Stereochemistry RACEMIC
Molecular Formula C24H33N3O4
Molecular Weight 427.5365
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RANOLAZINE

SMILES

COC1=C(OCC(O)CN2CCN(CC(=O)NC3=C(C)C=CC=C3C)CC2)C=CC=C1

InChI

InChIKey=XKLMZUWKNUAPSZ-UHFFFAOYSA-N
InChI=1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1-3H3,(H,25,29)

HIDE SMILES / InChI
Molecular Formula C24H33N3O4
Molecular Weight 427.5365
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:29:47 UTC 2023
Edited
by admin
on Fri Dec 15 16:29:47 UTC 2023
Record UNII
A6IEZ5M406
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RANOLAZINE
EMA EPAR   INN   MART.   MI   ORANGE BOOK   USAN   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
RANOLAZINE [USP-RS]
Common Name English
CVT-303
Code English
RAN D
Common Name English
RAN4
Common Name English
RANEXA
Brand Name English
(±)-N-(2,6-DIMETHYLPHENYL)-4-(2-HYDROXY-3-(2-METHOXYPHENOXY)PROPYL)-1-PIPERAZINEACETAMIDE
Systematic Name English
1-PIPERAZINEACETAMIDE, N-(2,6-DIMETHYLPHENYL)-4-(2-HYDROXY-3-(2-METHOXYPHENOXY)PROPYL)-, (±)-
Common Name English
Ranolazine [WHO-DD]
Common Name English
RANOLAZINE [EMA EPAR]
Common Name English
NSC-759100
Code English
N-(2,6-DIMETHYLPHENYL)-2-(4-((2RS)-2-HYDROXY-3-(2-METHOXYPHENOXY)PROPYL)PIPERAZIN-1-YL)ACETAMIDE
Systematic Name English
1-PIPERAZINEACETAMIDE, N-(2,6-DIMETHYLPHENYL)-4-(2-HYDROXY-3-(2-METHOXYPHENOXY)PROPYL)-
Systematic Name English
ASPRUZYO
Brand Name English
RS-43285-003
Code English
RANOLAZINE [VANDF]
Common Name English
RANOLAZINE [USAN]
Common Name English
RANOLAZINE [ORANGE BOOK]
Common Name English
ranolazine [INN]
Common Name English
RANOLAZINE [MART.]
Common Name English
RANOLAZINE [MI]
Common Name English
Classification Tree Code System Code
LIVERTOX NBK547932
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
WHO-VATC QC01EB18
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
EMA ASSESSMENT REPORTS RANEXA (AUTHORIZED: ANGINA PECTORIS)
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
NDF-RT N0000175427
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
WHO-ATC C01EB18
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
NCI_THESAURUS C93038
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
NCI_THESAURUS C78322
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL1404
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
RXCUI
35829
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY RxNorm
CAS
95635-55-5
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
USAN
QQ-33
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
SMS_ID
100000089164
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
FDA UNII
A6IEZ5M406
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
PUBCHEM
56959
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
INN
5946
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
DRUG CENTRAL
2359
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
EVMPD
SUB10259MIG
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
NSC
759100
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
RS_ITEM_NUM
1598744
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
NDF-RT
N0000182137
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY Cytochrome P450 2D6 Inhibitors [MoA]
MERCK INDEX
m9499
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY Merck Index
IUPHAR
7291
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
HSDB
7924
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
MESH
C055512
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
NDF-RT
N0000185503
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY P-Glycoprotein Inhibitors [MoA]
DAILYMED
A6IEZ5M406
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
NDF-RT
N0000187061
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY Organic Cation Transporter 2 Inhibitors [MoA]
CAS
142387-99-3
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
SUPERSEDED
NCI_THESAURUS
C66507
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
EPA CompTox
DTXSID3045196
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
CHEBI
87681
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
NDF-RT
N0000190114
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY Cytochrome P450 3A Inhibitors [MoA]
WIKIPEDIA
RANOLAZINE
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
DRUG BANK
DB00243
Created by admin on Fri Dec 15 16:29:48 UTC 2023 , Edited by admin on Fri Dec 15 16:29:48 UTC 2023
PRIMARY
Related Record Type Details
CYTOCHROME P450 2D6
METABOLIC ENZYME -> SUBSTRATE
MINOR
Structure of RANOLAZINE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> INHIBITOR
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
MAJOR
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> SUBSTRATE
Related Record Type Details
Structure of CVT-2513
METABOLITE -> PARENT
Structure of 2',6'-GLYCOLOXYLIDIDE
METABOLITE -> PARENT
Structure of CVT-3248
METABOLITE -> PARENT
Structure of N-(2,6-DIMETHYLPHENYL)OXAMIC ACID
METABOLITE -> PARENT
Structure of GUAIFENESIN
METABOLITE -> PARENT
Structure of GUAIFENESIN
METABOLITE -> PARENT
Structure of CVT-2551
METABOLITE -> PARENT
Structure of .BETA.-(2-METHOXYPHENOXY)LACTIC ACID
METABOLITE -> PARENT
Structure of CVT-2551
METABOLITE -> PARENT
Structure of CVT-3369
METABOLITE -> PARENT
Structure of CVT-2738
METABOLITE -> PARENT
primarily formed by CYP3A
MAJOR
PLASMA
Structure of CVT-3248
METABOLITE -> PARENT
Structure of DES-O-METHYL-O-SULFATE-RANOLAZINE
METABOLITE -> PARENT
Structure of CVT-2512
METABOLITE -> PARENT
By both CYP3A and CYP2D6
MAJOR
PLASMA
Structure of .BETA.-(2-METHOXYPHENOXY)LACTIC ACID
METABOLITE -> PARENT
Structure of CVT-2513
METABOLITE -> PARENT
Related Record Type Details
Structure of RANOLAZINE BIS(N-OXIDE)
IMPURITY -> PARENT
Structure of 1-PIPERAZINEACETAMIDE, 4-(3-(2-CHLOROPHENOXY)-2-HYDROXYPROPYL)-N-(2,6-DIMETHYLPHENYL)-
IMPURITY -> PARENT
Structure of 1,4-PIPERAZINEDIACETAMIDE, N,N'-BIS(2,6-DIMETHYLPHENYL)-
IMPURITY -> PARENT
Structure of RANOLAZINE ETHER DIMER
IMPURITY -> PARENT
Structure of DESMETHOXY RANOLAZINE
IMPURITY -> PARENT
Structure of P-RANOLAZINE
IMPURITY -> PARENT
Structure of M-RANOLAZINE
IMPURITY -> PARENT
Structure of N-(2,4-DIMETHYLPHENYL)-4-(2-HYDROXY-3-(2-METHOXYPHENOXY)PROPYL)-1-PIPERAZINEACETAMIDE
IMPURITY -> PARENT
Related Record Type Details
Structure of RANOLAZINE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Structure of RANOLAZINE
Elimination
PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC
Structure of RANOLAZINE
Elimination
PHARMACOKINETIC
NIH
NCATS
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