Migoprotafib

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H26N8O
Molecular Weight	454.5269
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@@H]1C2=CC=CC=C2OC13CCN(CC3)C4=NC5=C(N=C4)C(=NN5)N6CCCC7=C6C=CC=N7

InChI

InChIKey=RGCGBFIARQENML-JOCHJYFZSA-N

InChI=1S/C25H26N8O/c26-22-16-5-1-2-8-19(16)34-25(22)9-13-32(14-10-25)20-15-28-21-23(29-20)30-31-24(21)33-12-4-6-17-18(33)7-3-11-27-17/h1-3,5,7-8,11,15,22H,4,6,9-10,12-14,26H2,(H,29,30,31)/t22-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C25H26N8O
Molecular Weight	454.5269
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

C_max

Value	Dose	Co-administered	Analyte	Population
721 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/39632729/	60 mg single, oral dose: 60 mg route of administration: Oral experiment type: SINGLE co-administered:		MIGOPROTAFIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
850 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/39632729/	60 mg 1 times / day multiple, oral dose: 60 mg route of administration: Oral experiment type: MULTIPLE co-administered:		MIGOPROTAFIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
4410 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/39632729/	60 mg single, oral dose: 60 mg route of administration: Oral experiment type: SINGLE co-administered:		MIGOPROTAFIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
7340 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/39632729/	60 mg 1 times / day multiple, oral dose: 60 mg route of administration: Oral experiment type: MULTIPLE co-administered:		MIGOPROTAFIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
23.5 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/39632729/	60 mg single, oral dose: 60 mg route of administration: Oral experiment type: SINGLE co-administered:		MIGOPROTAFIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
23.5 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/39632729/	60 mg 1 times / day multiple, oral dose: 60 mg route of administration: Oral experiment type: MULTIPLE co-administered:		MIGOPROTAFIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

Substance Class	Chemical Created by `admin` on `Wed Apr 02 00:59:25 GMT 2025` Edited by `admin` on `Wed Apr 02 00:59:25 GMT 2025`
Record UNII	ABR1HZ0ZG8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GDC-1971

Preferred Name

English

Migoprotafib

Official Name

English

Migoprotafib [WHO-DD]

Common Name

English

RLY-1971

Code

English

RG6433

Code

English

RG-6433

Code

English

RO-7517834

Code

English

Spiro[benzofuran-2(3H),4?-piperidin]-3-amine, 1?-[3-(3,4-dihydro-1,5- naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-

Systematic Name

English

RO7517834

Code

English

migoprotafib [INN]

Common Name

English

(3R)-1?-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-3H-spiro[[1]benzofuran-2,4?-piperidin]-3-amine

Systematic Name

English

MIGOPROTAFIB [USAN]

Common Name

English

RTX-1084260

Code

English

Code System Code Type Description

NCI_THESAURUS

C199073