Labafenogene Marselecobac

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NCATS

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 15:39:08 GMT 2025` Edited by `admin` on `Wed Apr 02 15:39:08 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	BACTERIUM
Organism Family	Enterobacteriaceae
Organism Genus	Escherichia
Organism Species	escherichia coli
Infraspecific Type	STRAIN:SUBSTRAIN
Infraspecific Name	SYNB1934 (E.coli/LAAD/PheP/mPAL/del dapA/Inactivation of the endogenous Nissle prophage)
Part	whole
Record UNII	ABR4S53CKC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SYNB-1934

Preferred Name

English

Labafenogene Marselecobac

Official Name

English

labafenogene marselecobac [INN]

Common Name

English

SYNB1934

Code

English

LABAFENOGENE MARSELECOBAC [USAN]

Common Name

English

recombinant live Escherichia coli strain Nissle 1917 (EcN) bacteria, genetically engineered as follows: a) Insertion across the genome of four copies of a modified phenylalanine ammonia lyase (mPAL) gene from Photorhabdus laumondii subsp. laumondii with

Common Name

English

Engineered bacterium derived from Escherichia coli Nissle 1917 (EcN) that has been designed to treat phenylketonuria (PKU) by consuming and converting phenylalanine (Phe) to the nontoxic metabolites trans-cinnamic acid (TCA) and phenylpyruvate (PP).

Common Name

English

Code System Code Type Description

USAN

MN-14

Created by admin on Wed Apr 02 15:39:08 GMT 2025 , Edited by admin on Wed Apr 02 15:39:08 GMT 2025

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FDA UNII

ABR4S53CKC

Created by admin on Wed Apr 02 15:39:08 GMT 2025 , Edited by admin on Wed Apr 02 15:39:08 GMT 2025

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SMS_ID

300000037260

Created by admin on Wed Apr 02 15:39:08 GMT 2025 , Edited by admin on Wed Apr 02 15:39:08 GMT 2025

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INN

12595

Created by admin on Wed Apr 02 15:39:08 GMT 2025 , Edited by admin on Wed Apr 02 15:39:08 GMT 2025

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NCI_THESAURUS

C199064

Created by admin on Wed Apr 02 15:39:08 GMT 2025 , Edited by admin on Wed Apr 02 15:39:08 GMT 2025

PRIMARY

Related Record Type Details


					72H28PHD6P

Labafenogene marselecobac expressed enzyme phenylalanine ammonia lyase

EXPRESSED PROTEIN->VECTOR

Amount:


					V2I5FAS6Y5

ESCHERICHIA COLI STRAIN NISSLE 1917

PARENT ORGANISM -> INFRASPECIFIC

Amount:


					U57G6AB66P

Phenylalanine-specific permease (Escherichia coli (strain K12))

EXPRESSED PROTEIN->VECTOR

Amount:


					K25E32Q8DL

Amino acid deaminase (Proteus mirabilis (strain HI4320))

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					ABR4S53CKC

Labafenogene Marselecobac

ACTIVE MOIETY

Comments:

SYNB1934 is an engineered strain of Escherichia coli Nissle 1917 (EcN) that has been designed for the treatment of Phenylketonuria (PKU) through the conversion of phenylalanine to trans-cinnamic acid (TCA) and phenylpyruvate (PP), two nontoxic metabolites

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR		inserted downstream of the endogenous Nissle araC gene			Labafenogene marselecobac LacI-Ptac-mPAL insertion	BM7DPF4Z6U
INSERTED GENE EXPRESSION VECTOR					Labafenogene marselecobac PBAD-LAAD insertion	N29C69W7VN
INSERTED GENE EXPRESSION VECTOR					Labafenogene marselecobac LacI-Ptac-pheP insertion	AXL2C5DY5R