Ufrenmeran

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NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 15:25:02 GMT 2025` Edited by `admin` on `Wed Apr 02 15:25:02 GMT 2025`
Nucleic Acid Type	MRNA
Sequence Type	COMPLETE
Record UNII	AP7FFK83RM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Ufrenmeran

Official Name

English

RNA (recombinant 5?-(m7G-(5??5?)-ppp-Am)-capped all cytidine?5-methylcytidine, all uridine?5-methyluridine human ?-globin 5?-untranslated region plus severe acute respiratory syndrome coronavirus 2 strain Wuhan-Hu-1 (1-13)-(319-541)-spike glycoprotein pr

Preferred Name

English

Ufrenmeran [WHO-DD]

Common Name

English

messenger RNA (mRNA), 5'-capped, encoding the codon-optimized receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, Wuhan-Hu-1 isolate, GenBank: MN908947.3) spike (S) glycoprotein, expressed as a fusion protein

Common Name

English

ufrenmeran [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C190418

Created by admin on Wed Apr 02 15:25:02 GMT 2025 , Edited by admin on Wed Apr 02 15:25:02 GMT 2025

PRIMARY

CAS

2749556-96-3

Created by admin on Wed Apr 02 15:25:02 GMT 2025 , Edited by admin on Wed Apr 02 15:25:02 GMT 2025

PRIMARY

FDA UNII

AP7FFK83RM

Created by admin on Wed Apr 02 15:25:02 GMT 2025 , Edited by admin on Wed Apr 02 15:25:02 GMT 2025

PRIMARY

SMS_ID

300000054869

Created by admin on Wed Apr 02 15:25:02 GMT 2025 , Edited by admin on Wed Apr 02 15:25:02 GMT 2025

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INN

12540

Created by admin on Wed Apr 02 15:25:02 GMT 2025 , Edited by admin on Wed Apr 02 15:25:02 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_1022	1022 / 1022

Linkage	Site Range	Site Count
Phosphate	1_2-1_1022	1021 / 1021

Related Record Type Details


					YT6ZGY2CE2

SARS COV-2 RECEPTOR BINDING DOMAIN

EXPRESSED PROTEIN->VECTOR

Amount:


					B6L4N5Z4GH

SARS-COV2

TARGET->VACCINE ANTIGEN

Amount:

Related Record Type Details


					AP7FFK83RM

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE INSERTIONS	[1_1]	5'-TERMINUS			m2-7,3’-OGppp(m1-2’-O)Ap mRNA CAP	VNP8CZY34V
NUCLEOSIDE BASE SUBSTITUTION		RESIDUE_SPECIFIC	C		5-METHYLCYTOSINE	6R795CQT4H
NUCLEOSIDE BASE SUBSTITUTION		RESIDUE_SPECIFIC	U		THYMINE	QR26YLT7LT